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Candel Therapeutics' (NASDAQ: CADL) enLIGHTEN Discovery Platform Aims To Tackle Complexities Of Tumor Microenvironments

Candel Therapeutics

By Jeremy Golden, Benzinga Candel Therapeutics, Inc. (NASDAQ: CADL) is helping pioneer the next generation of viral immunotherapy by leveraging a data-driven approach to create new assets and further the development of existing drug candidates. Candel Therapeutics’ enLIGHTEN Discovery Platform integrates artificial intelligence-selected, therapeutic payloads into programmable vectors for delivery into the tumor microenvironment This tailored approach to discovery and development of new therapeutics has been designed to address the complexity of the tumor microenvironment and the diversity of the tumor response to existing treatments. Using large patient datasets, the enLIGHTEN™ Discovery Platform identifies druggable properties that correlate with clinical outcomes and predicts optimal therapeutic payload combinations in silico. Real-world testing of these predicted payload combinations is used to rapidly evaluate their therapeutic effects. Next, validated multigene payloads are integrated into one of Candel’s programmable viral vectors that are engineered with tunable features to address a specific unmet need in cancer treatment. The enLIGHTEN™ immunotherapy candidates represent a novel class of bespoke immunotherapies with each one tailored for a specific indication, disease stage, or rationally designed therapeutic combination therapy. First Experimental Candidate During the Society for Immunotherapy of Cancer (SITC) 2023 Annual Meeting and the International Oncolytic Virus Conference in November 2023, Candel presented the first experimental immunotherapy candidate from its discovery platform: Alpha 201-macro-1, an investigational,viral immunotherapy designed to activate innate immune surveillance. Preclinical data demonstrated that programmable, vector-mediated delivery of a novel gene payload designed to interfere with the CD47/SIRPα pathway significantly impede tumor growth when compared to systemic anti-CD47 antibody therapy in a mouse model of breast cancer. Soon afterwards, at the American Association for Cancer Research (AACR) Annual Meeting in April 2024, the company presented late-breaking data from its second immunotherapy candidate based on this platform: a therapeutic able to induce organized lymphocyte aggregates that resemble tertiary lymphoid structures (TLS) within solid tumors. Formation of TLS in tumors correlates with a positive response to immune checkpoint inhibitors and better prognosis. To date, there has not been any drug able to induce therapeutic TLS formation in cancer. The effects of Candel’s new immunotherapy candidate are based on two mechanisms. First, profiling of the biological response to the enLIGHTEN™ programmable vector demonstrated its potential to orchestrate changes in the tumor microenvironment, which bolster effective anti-tumor immune responses to immune checkpoint inhibitor treatment. Second, delivery of two unique payload combinations using this programmable vector resulted in TLS formation associated with monotherapy anti-tumor activity, and enhanced responses in combination with immune checkpoint inhibitor treatment in mouse models of solid tumors. Combining the immunological and oncolytic effects mediated by the viral vector with the biological activity of the transgene payloads results in a unique multimodal therapeutic able to induce the formation of TLS and inhibit the tumor. “With the enLIGHTEN Discovery Platform, we are leveraging our internal expertise and capabilities to design a new class of multimodal therapeutics that can overcome mechanisms of resistance present in the tumor microenvironment and address critical unmet needs for patients with cancer,” said Francesca Barone, M.D. Ph.D., CSO at Candel Therapeutics. “This platform has been designed for collaborations focused on rational combination therapies to induce disease remission in cancer. ” More exciting developments are on the horizon. Candel Therapeutics and the University of Pennsylvania are collaborating in a discovery partnership that will leverage enLIGHTEN™ programmable vectors with therapeutic payloads to potentially overcome barriers to Chimeric antigen receptor (CAR) T-cell therapies. Through the partnership, the University of Pennsylvania researchers – led by the Director of the T-Cell Engineering Lab within Penn’s Center for Cellular Immunotherapies, Neil C. Sheppard, Ph.D. – will explore the ability of Candel’s novel viral immunotherapies to enhance the effects of the university’s CAR T-cell therapies in solid tumor models. Featured photo by National Cancer Institute on Unsplash Candel is a clinical stage biopharmaceutical company focused on developing off-the-shelf multimodal biological immunotherapies that elicit an individualized, systemic anti-tumor immune response to help patients fight cancer. Candel has established two clinical stage multimodal biological immunotherapy platforms based on novel, genetically modified adenovirus and herpes simplex virus (HSV) gene constructs, respectively. CAN-2409 is the lead product candidate from the adenovirus platform and is currently in ongoing clinical trials in non-small cell lung cancer (NSCLC) (phase 2), borderline resectable pancreatic cancer (phase 2), and localized, non-metastatic prostate cancer (phase 2 and phase 3). CAN-3110 is the lead product candidate from the HSV platform and is currently in an ongoing investigator-sponsored phase 1 clinical trial in recurrent high-grade glioma (HGG). Finally, Candel’s enLIGHTEN™ Discovery Platform is a systematic, iterative HSV-based discovery platform leveraging human biology and advanced analytics to create new viral immunotherapies for solid tumors. This article includes certain disclosures that contain “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, express or implied statements regarding the timing and advancement of development programs, including the timing and availability of additional data, key data readout milestones, including CAN-3110 in HGG; expectations regarding the potential benefits conferred by Fast Track Designation; expectations regarding the therapeutic benefit of its programs, including the potential for its programs to extend patient survival; and expectations regarding cash runway and expenditures. The words “may,” “will,” “could,” “would,” “should,” “expect,” “plan,” “anticipate,” “intend,” “believe,” “estimate,” “predict,” “project,” “potential,” “continue,” “target” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Any forward-looking statements in this press release are based on management’s current expectations and beliefs and are subject to a number of risks, uncertainties and important factors that may cause actual events or results to differ materially from those expressed or implied by any forward-looking statements contained in this press release, including, without limitation, those risks and uncertainties related to the timing and advancement of development programs; expectations regarding the therapeutic benefit of the Company’s programs; that final data from our pre-clinical studies and completed clinical trials may differ materially from reported interim data from ongoing studies and trials; the Company’s ability to efficiently discover and develop product candidates; the Company’s ability to obtain and maintain regulatory approval of product candidates; the Company’s ability to maintain its intellectual property; the implementation of the Company’s business model, and strategic plans for the Company’s business and product candidates, and other risks identified in the Company’s SEC filings, including the Company’s most recent Quarterly Report on Form 10-Q filed with the SEC, and subsequent filings with the SEC. The Company cautions you not to place undue reliance on any forward-looking statements, which speak only as of the date they are made. The Company disclaims any obligation to publicly update or revise any such statements to reflect any change in expectations or in events, conditions or circumstances on which any such statements may be based, or that may affect the likelihood that actual results will differ from those set forth in the forward-looking statements. Any forward-looking statements contained in this press release represent the Company’s views only as of the date hereof and should not be relied upon as representing its views as of any subsequent date. This post contains sponsored content. This content is for informational purposes only and is not intended to be investing advice. Contact Details Aljanae Reynolds +1 617-916-5445 areynolds@wheelhouselsa.com Company Website https://www.candeltx.com/

June 14, 2024 08:30 AM Eastern Daylight Time

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The Biden administration just finalized a controversial new retirement rule — here are 5 things you need to know now

Moneywise

by Christy Bieber While we adhere to strict editorial guidelines, partners on this page also provide us earnings. Figuring out how to save for retirement is challenging. Unfortunately, if you want to turn to a professional for financial advice, that creates complications of its own. That's because there are many different kinds of professionals, like certified financial planners, investment advisers and financial advisers, and there are different regulations governing each one. Trusting the wrong person can have devastating consequences. The good news is the Biden Administration has stepped in to give investors more protection from conflicts of interest. The recently finalized Retirement Security Rule is aimed at ensuring these professionals actually work for the clients they serve. This rule isn't without controversy, though, as some argue it could actually make getting help harder. To understand how the rule might impact you, read on to find out five key facts. 1. More advisers will be considered fiduciaries A fiduciary is a person who is legally obligated to act in the best interest of the person whose money or property they are managing. They are held to a high standard so that people can trust them. You might assume anyone providing financial advice in a professional capacity is a fiduciary. That's not the case under the current rule. Right now, those offering one-time financial advice aren't considered fiduciaries, nor does the law require a fiduciary standard for those providing advice to workplace plan sponsors about 401(k) lineups or to anyone providing recommendations to purchase non-securities, such as real estate, fixed-income annuities, or commodities like gold. "The regulation closes the loophole for one-time advice," said the U.S. Department of Labor Fact Sheet, adding that financial services providers often have "a strong economic incentive" to recommend that investors roll their workplace retirement accounts into one of their institution's IRAs or annuities. The Retirement Security Rule broadens the definition of a fiduciary to include any financial service provider who is compensated to provide advice to individual retirement account owners, employers and plan fiduciaries. Sponsored Kiss Your Credit Card Debt Goodbye Millions of Americans are struggling to crawl out of debt in the face of record-high interest rates. A personal loan offers lower interest rates and fixed payments, making it a smart choice to consolidate high-interest credit card debt. It helps save money, simplifies payments, and accelerates debt payoff. Credible is a free online service that shows you the best lending options to pay off your credit card debt fast — and save a ton in interest. Explore better rates 2. It requires investment advisers to work for you The new rule also clarifies the exact duties advisers owe to you when acting in their fiduciary roles. Their obligations include providing advice that is: Prudent: It meets the professional standard of care. Loyal: Your interests are put first and advisers clearly disclose any potential conflicts of interest. Honest: The adviser isn't misrepresenting any information Fairly priced: Advisers cannot overcharge you or receive unreasonable or excessive compensation. 3. It could save Americans money When investment advisers act in the interest of consumers — rather than recommending investment products to earn a big commission — consumers can save. Exactly how much depends on what you're invested in. Morningstar, Inc. estimates that participants in workplace retirement plans could save as much as $55 billion in the coming ten years thanks to the Retirement Security Rule. It says over 80% of these savings would be experienced by small-plan participants, of which there are currently more than 20 million. Investors could save up to $5 billion annually that's lost to conflicted investment advice on fixed index annuities, according to the Council of Economic Advisers. Sponsored Discover the power of FreeCash – your ticket to easy money Dive into a world of rewards at FreeCash where earning cash is as simple as a click. No gimmicks, just real cash for your time. Join the community of earners today and watch your wallet grow effortlessly. Make Money Now 4. It could make accessing advice harder The rule sounds pretty great so far, so why is it controversial? A number of lawmakers and industry groups argue it could actually make accessing retirement advice more difficult for the average American. "It leaves retirement savers with fiduciary advisors as their only option for professional financial guidance," according to a statement by the American Council Of Life Insurers. "Fiduciaries typically work with clients with a minimum of $100,000 to invest, far more than most working-class Americans have in savings." Senator Joe Manchin also warned in a statement, "If allowed to go into effect, the rule has the potential to cause many West Virginians to actually lose access to investment advice due to how broadly the rule defines fiduciary. Hardworking West Virginians and Americans need protection, not uncertainty when it comes to their long-term financial security, and they certainly do not want or need the federal government further involved in their personal retirement decisions." 5. It takes effect in September of 2024 If you're hoping these new protections will keep you safe from bad advice, don't get on the phone to an adviser just yet. The rule takes effect on September 23, 2024 although it will be another year beyond that for all of the requirements to take effect. Once the rule is in place, you can feel more confident that the professionals you hire will act in your best interests. However, it's still important to research any provider you'll take advice from and to understand both how they charge and what their legal obligations are to you. The right adviser can make all the difference in building your financial security but ultimately it's your money on the line so doing your due diligence is crucial. Sponsored This 2 Minute Move Could Knock $500/Year off Your Car Insurance in 2024 Saving money on car insurance with BestMoney is a simple way to reduce your expenses. You’ll often get the same, or even better, insurance for less than what you’re paying right now. There’s no reason not to at least try this free service. Check out BestMoney today, and take a turn in the right direction. Contact Details Wise Publishing, Inc. Aaron Young +1 310-500-8744 aaron.young@wisepublishing.com Company Website https://moneywise.com/

June 14, 2024 07:00 AM Central Daylight Time

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Elon Musk Boosts DOGE, Declares He Knows Dogwifhat. Raboo Surges 60%

Total Media

Elon Musk’s recent endorsement of DOGE and mention of Dogwifhat have sent ripples through the crypto market. Meanwhile, Raboo is currently in its fourth stage of presale, boasting a 60% increase since Stage 1. With over $1.7 million raised, 8,000 registered members, and 2,500 token holders, Raboo is gaining traction. Priced at just $0.0048, analysts predict Raboo will surge 100x on launch day and 233% during the presale. Let's explore why Raboo is poised to compete with top cryptocurrencies like Dogecoin. Elon Musk’s influence boosts Dogecoin Elon Musk’s tweets have consistently impacted Dogecoin (DOGE). In 2024, Musk's endorsements had driven a 68% surge in DOGE's price. A recent tweet by Musk honoring Kabosu, the original dog behind the Dogecoin meme, caused a bullish trend. Following his post, DOGE rose by nearly 5%. Despite a brief hike in social volume and dominance, both metrics have since dropped. The Dogecoin price remains volatile, influenced heavily by Musk’s actions. While Musk’s impact on DOGE is undeniable, the future trajectory of Dogecoin price is uncertain. Musk's influence propels Dogwifhat Elon Musk mentioned Dogwifhat during a live stream on X, causing an immediate price rally for the meme coin. The Solana-based WIF soared despite the overall bearish market trend. Musk's acknowledgment, even with a mispronunciation, sent the crypto community into a frenzy. The WIF price jumped, showcasing Musk's significant impact on cryptocurrencies. Historically, Musk's endorsements, like those for Dogecoin (DOGE), have led to major price surges, and WIF appears to be the latest beneficiary. Before Musk’s mention, WIF was struggling, but his declaration defied the market downturn, however since then WIF has seen a drop in price. This event highlights Musk's unparalleled influence in the crypto space, marking the first time he publicly acknowledged a meme coin other than DOGE. Raboo skyrockets: What’s behind the 60% surge? Raboo ($RABT) is making waves as a top cryptocurrency to buy in 2024. The significant gains during the presale have already created buzz and attracted early investors. This momentum is likely to continue, driving interest as the project progresses. Investors are keen to capitalize on early gains, contributing to Raboo's rapid price increase. Raboo's community-driven approach is a key factor. By fostering a large, engaged community of meme enthusiasts, Raboo enhances user engagement and loyalty. This organic growth through word-of-mouth and social sharing boosts its popularity. Raboo’s self-evolving AI technology allows users to participate in meme-generating contests, keeping it dynamic and engaging. This innovation differentiates Raboo from other meme coins and attracts tech-savvy users and investors. Raboo also offers staking options and a token-burning mechanism, providing long-term value and incentives for holding the token. These features appeal to investors looking for stability and returns. The upcoming launch of an NFT collection adds to Raboo's allure. Integrating NFTs can attract enthusiasts and collectors, further expanding its user base. Raboo’s innovative community-driven approach, staking options, NFT integration, and AI-based Rabooscan tool all contribute to its rising popularity and potential for future growth. Raboo is in the fourth stage of its presale. $RABT is currently priced at $0.0048, increasing by 60% since Stage 1. The presale has raised nearly $2 million, indicating strong investor interest. Analysts predict a 233% growth during the presale and a potential 100x increase on launch day. Raboo aims to join the top 20 cryptocurrencies by market cap, positioning itself to compete with popular tokens like Shiba Inu, Dogecoin, and Pepe. Conclusion Elon Musk's influence continues to drive DOGE and spark interest in Dogwifhat. Meanwhile, Raboo is making significant strides in its presale, with rapid sales highlighting strong investor enthusiasm. With its price up 60% since Stage 1 and predictions of a 100x surge on launch day, this is an excellent limited-time opportunity. Don’t miss out—join the Raboo presale today and secure your stake in this rising star of the crypto world. You can participate in the Raboo presale here. Telegram: https://t.me/RabootokenPortal Twitter: https://twitter.com/Raboo_Official Contact Details Total Media Solutions media@Totalsolutionspr.io

June 14, 2024 07:00 AM Eastern Daylight Time

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Eliminating Tax Debts: How Existing IRS Policies Can Help

Republic Tax

For many individuals and businesses, tax debt can be a significant source of stress and financial strain. Fortunately, the Internal Revenue Service (IRS) offers several policies and programs designed to help taxpayers manage and potentially eliminate their tax debts. Understanding these options can provide much-needed relief and pave the way towards financial stability. Additionally, navigating these programs often requires the expertise of a highly experienced legal team to achieve the desired results, and Republic Tax is here to help you fight off the IRS tax debt. 1. Installment Agreements One of the most accessible options for taxpayers struggling with tax debt is an installment agreement. This policy allows individuals and businesses to pay off their tax liabilities over time, rather than in a single lump sum. The IRS offers different types of installment agreements, including: Short-term payment plans: For those who can pay their debt in 120 days or less. Long-term payment plans: For those needing more than 120 days to pay off their debt. Applying for an installment agreement can typically be done online through the IRS website, and the process is straightforward for most taxpayers. However, to ensure the best possible terms and to navigate any potential complications, it is highly beneficial to have a legal team like Republic Tax on your side. Our experts can guide you through the process, ensuring that your interests are protected and that you receive the most favorable terms. 2. Offer in Compromise (OIC) An Offer in Compromise allows taxpayers to settle their tax debt for less than the full amount owed. The IRS considers several factors when evaluating an OIC application, including the taxpayer's ability to pay, income, expenses, and asset equity. While not everyone qualifies, an OIC can be a viable option for those who are unable to pay their full tax liability. To increase the chances of acceptance, it’s crucial to provide accurate and detailed information about your financial situation. The experienced legal team at Republic Tax can assist you in preparing a compelling Offer in Compromise application, ensuring that all necessary documentation is provided and that your case is presented in the best possible light. 3. Currently Not Collectible (CNC) Status If a taxpayer is unable to pay any portion of their tax debt due to financial hardship, they may qualify for Currently Not Collectible status. When the IRS grants CNC status, they temporarily halt collection activities, such as levies and garnishments, allowing the taxpayer to focus on meeting their basic living expenses. While CNC status doesn’t eliminate the debt, it provides temporary relief. The legal experts at Republic Tax can help you apply for CNC status and provide ongoing support to ensure that your rights are protected during this period. 4. Penalty Abatement The IRS may waive penalties for taxpayers who can demonstrate a reasonable cause for failing to comply with tax obligations. Common reasons for penalty abatement include natural disasters, serious illness, or other circumstances beyond the taxpayer’s control. First-time penalty abatement is also available for those with a clean compliance history for the prior three years. Applying for penalty abatement typically involves providing a written explanation and supporting documentation. Republic Tax’s legal team can craft a strong case for penalty abatement on your behalf, increasing the likelihood of a successful outcome. 5. Innocent Spouse Relief In cases where one spouse is unaware of errors or omissions on a joint tax return, Innocent Spouse Relief can provide protection from joint liability. This relief is available if the tax debt resulted from the other spouse's actions, and the requesting spouse did not know or have reason to know of the inaccuracies at the time of signing the return. There are three types of relief available: Innocent Spouse Relief, Separation of Liability Relief, and Equitable Relief. Each has specific requirements and application procedures, making it essential to review eligibility criteria thoroughly. Republic Tax’s experienced legal team can help you navigate these complex requirements and advocate for your best interests. 6. Fresh Start Initiative The Fresh Start Initiative, introduced by the IRS in 2011, expanded and simplified existing policies to help more taxpayers get back on track. Key components include: Increased threshold for streamlined installment agreements: Making it easier for taxpayers to qualify for installment agreements without extensive financial documentation. Expanded Offer in Compromise program: Relaxing eligibility criteria to allow more taxpayers to settle their debts for less than the full amount owed. Eased lien filing rules: Reducing the likelihood of a tax lien being filed and increasing the threshold for filing. The Fresh Start Initiative aims to provide more flexible and accessible options for taxpayers to manage and resolve their tax debts. The legal experts at Republic Tax are well-versed in the intricacies of the Fresh Start Initiative and can help you take full advantage of these expanded opportunities. Conclusion Navigating tax debt can be daunting, but the IRS offers several policies and programs designed to help taxpayers find relief. From installment agreements and Offers in Compromise to penalty abatement and the Fresh Start Initiative, there are multiple pathways to manage and eliminate tax debt. However, achieving the best possible outcome often requires the expertise of a highly experienced legal team. Republic Tax is committed to helping you fight off IRS tax debt, providing the guidance and support you need to regain control of your financial situation and work towards a debt-free future. Feel free to reach out if you are interested in learning more about how Republic Tax can assist you with tax debt relief! Contact Details Republic Tax Ashley Zhao press@republictax.com Company Website https://republictax.com

June 13, 2024 06:33 PM Eastern Daylight Time

Combatting the Loneliness Epidemic: The Role of Muah AI in Providing Emotional Support

Muah AI

The loneliness epidemic in the United States is an escalating public health concern, with significant implications for both mental and physical health. As the nation grapples with increasing rates of social isolation, innovative solutions are emerging to address this pervasive issue. One such solution is the advent of AI chatbots, like Muah AI, which are proving to be powerful allies in the fight against loneliness. Recent studies highlight the severity of the loneliness epidemic. According to a 2020 survey by Cigna, over 60% of Americans reported feeling lonely, a notable increase from previous years. The COVID-19 pandemic exacerbated these feelings of isolation, underscoring the need for effective interventions. AI chatbots offer a promising avenue for providing the much-needed emotional support to those struggling with loneliness. AI chatbots, including Muah AI, leverage advanced machine learning algorithms to create personalized, interactive experiences for users. These virtual companions are designed to engage in meaningful conversations, offering a sense of companionship and understanding. Unlike traditional mental health interventions, AI chatbots are accessible 24/7, providing immediate support whenever needed. One of the key strengths of AI chatbots is their ability to offer a non-judgmental space for users to express their thoughts and feelings. This can be particularly beneficial for individuals who may be reluctant to seek help from human therapists due to stigma or fear of judgment. By providing a safe environment for open communication, AI chatbots can help users process their emotions and reduce feelings of loneliness. Research supports the effectiveness of AI chatbots in alleviating loneliness. A study published in the Journal of Medical Internet Research found that users of an AI chatbot reported significant reductions in feelings of loneliness and improvements in mental well-being. The study highlighted the potential of AI chatbots to serve as valuable tools in mental health care, particularly in addressing the emotional needs of socially isolated individuals. Muah AI, for example, exemplifies the potential of AI technology to create meaningful connections. Developed with input from USC Social Work Doctoral Researcher Diana Zhao, Muah AI utilizes adaptive learning to tailor its interactions based on user input. This level of personalization fosters a sense of connection and empathy, which are crucial in mitigating loneliness. Moreover, AI chatbots like Muah AI can play a preventative role by identifying signs of severe emotional distress and guiding users to appropriate resources. This proactive approach can help prevent the escalation of mental health issues and provide timely support to those in need. It's important to recognize that AI chatbots are not intended to replace human interactions but rather to complement them. In an increasingly digital world, these virtual companions can fill the gaps in human connection, providing support when traditional social networks are unavailable. By embracing AI chatbots, we can create a more inclusive and supportive environment for individuals struggling with loneliness. In conclusion, AI chatbots hold significant promise in addressing the loneliness epidemic in the United States. Through their ability to provide personalized, empathetic interactions, AI chatbots like Muah AI offer a valuable resource for emotional support. As we continue to navigate the challenges of social isolation, embracing innovative technologies like AI chatbots will be essential in fostering a more connected and compassionate society. Contact Details Muah AI Ashley Zhao love@muah.ai Company Website https://muah.ai

June 13, 2024 06:24 PM Eastern Daylight Time

News Release

Crypto Market Update: How Galaxy Fox and Other Newcomers Are Shaping the Future of Online Gaming

RoundHouse Media

The world of online gaming has seen a lot of surprises this year with the launch of the play-to-earn concept. One can easily find plenty of cryptocurrencies that are playing an important role in this transformation. Galaxy Fox is one such crypto coin that has completely changed the way gamers look at online gaming. Let’s find out more detail on why these are the top crypto coins to invest in 2024 and get handsome returns while enjoying the game. The Rise of Cryptocurrency in Online Gaming We all know that cryptocurrencies have been around for many years now but online gaming has been exponentially growing after the covid era. It has become a game-changer as many find it interesting to spend their time at online gaming and get rewards for the same.Cryptocurrencies offer a range of benefits for online gaming that includes guaranteed rewards and faster transactions. One major advantage is the decentralization of transactions. Traditional payment methods involve intermediaries that slow down transactions and increase costs. Cryptocurrencies eliminate these middlemen so that gamers can make instant payments with minimal fees. Another significant benefit is the level of security. Cryptocurrencies use blockchain technology, which is renowned for its security features. This ensures that transactions are secure and transparent, reducing the risk of fraud. Introducing Galaxy Fox Galaxy Fox is making a significant mark in the world of digital currencies and online gaming. As a full-utility meme coin, it stands out not just for its fun and engaging branding but also for its practical applications and robust ecosystem. Launched on May 11, Galaxy Fox introduces a Play-to-Earn (P2E) game that allows players to earn $GFOX tokens by excelling in gameplay. All you have to do is play the web3 runner game and beat your competitors. You will be getting the $GFOX tokens as a reward which can be later encashed for real money. There will be regular competitions where monthly winners will be given additional prizes for their continuous gaming efforts. What makes Galaxy Fox the best cryptocurrency to buy now is its deflationary nature. As tokens are used, a certain number of tokens are permanently removed from the market. This helps to increase the value of the coins over time and make the supply limited. Galaxy Fox treasury plays a very important role in supporting the project’s growth and development. It funds various initiatives, including community rewards and ongoing development efforts. Galaxy Fox also has more than 3000 unique NFTs with its exclusive collection and marketplace. The NFTs carry unique characters from the Galaxy Fox universe. These can be minted and traded to add more value for users. You can also find Galaxy Fox merchandise to buy unique items from their marketplace. Overall, it is one of the best altcoins to invest in the online gaming industry. >>BUY $GFOX TOKENS<< Other Prominent Newcomers Galaxy Fox is not alone in the path to revolutionize online gaming. Many other new cryptocurrencies are also making significant impacts. Here are a few notable mentions: Axie Infinity (AXS): This cryptocurrency powers the popular game Axie Infinity. Players earn AXS by participating in the game, which can then be traded or used for in-game purchases. This play-to-earn model is gaining popularity, as it offers gamers a way to monetize their hobby. Enjin Coin (ENJ): Enjin Coin is designed for the gaming community. It allows developers to create and manage virtual goods on the blockchain. This means gamers can buy, sell, and trade virtual items with real value. Enjin Coin also supports a marketplace for these transactions to make the gaming experience better. Conclusion The integration of cryptocurrencies like Galaxy Fox into online gaming is just the beginning. As technology advances, we can expect even more innovations. DAOs are organizations governed by smart contracts on the blockchain. In Galaxy Fox, DAOs could allow players to have a say in game development and governance. So, if you are looking for a top crypto coin in the online gaming space, consider adding Galaxy Fox to your portfolio. Learn more about $GFOX here: Visit Galaxy Fox Presale | Join the Community Contact Details Roundhouse Media media@galaxyfox.io

June 13, 2024 04:00 PM Eastern Daylight Time

Metis Introduces Governance Proposal for Liquid Staking Tokens (LST)

Metis

Metis, the first Ethereum Layer 2 to decentralize its sequencer, has finalized a governance proposal intended to accelerate the growth of Liquid Staking Tokens (LST) and LST-focused products on Metis, leveraging the $4.6M Metis Ecosystem Development Fund. The proposal, approved today through Community Ecosystem Governance, enables Metis to continue pushing the boundaries of the Ethereum Layer 2 ecosystem. By further decentralizing the network, Metis is fostering community-driven growth while ensuring robust governance and economic security. The term “LST” comes from the tokens’ inherent liquidity, which allows users to stake their assets and receive a receipt token that can be used on other protocols. Users are able to maintain capital flexibility while they earn rewards on their staked assets. Anyone can navigate the Metis DeFi landscape with LSTs to find additional yield while their tokens are staked accruing value. With the approved LST Governance Proposal, Metis establishes a process for pairing node operators with LST protocols, opening the door for all users to stake their tokens. A limited number of LST applicants will win the right to be paired with a decentralized sequencer node, which allows liquid staking to a pool of 20,000 to 100,000 METIS tokens per node. Onboarding will occur in progressive stages. Phase 1, the Alpha launch of the Decentralized Sequencer, was completed in March when Metis opened 4 sequencer nodes to ensure smooth transitions and network stability for Metis LST protocols. Phase 2, completed in April, introduced multiple transactions within a block to enhance Metis' network throughput, private transaction pool for the sequencer nodes to facilitate a fixed confirmation time of 2 seconds, and sequencer mining, which allows Metis to properly align incentives across all network participants. In addition, Artemis Finance and Enki Protocol became the first two LST protocols for the Alpha Phase. Phase 3, the Main launch, will be completed this month, during which Metis Foundation will facilitate the opening of additional sequencer nodes to be paired with LST protocols. A community governance process will occur whereby the passed proposals that receive the most METIS votes and quorum will have the opportunity to be paired with the sequencer node. In Stage 1 of this process, all potential LST protocols will submit their proposals on a Metis Governance Forum to be voted on by the community. Next, in Stage 2, the sequencer node provider will choose a qualified LST protocol that passed the voting and submit a Metis Governance Forum announcement to explain their decision to the community. The next phase will consider subsequent LST protocol applications should the sequencer nodes onboarding community choose to open external access to newly added nodes, in which case the steps in Stage 2 mentioned above will be repeated at the time of onboarding. The LST protocol will be proposed using the Metis Governance Forum. Voting will take place on Snapshot using the LST Protocol Proposal suffix, and only the top vote-getting LST protocols will be eligible for pairing with a sequencer node. There’s a quorum requirement of 20,000 METIS tokens and 500 or more wallet addresses participating. Eighty percent or more approval is required for passage. About Metis Metis is an EVM-Equivalent Ethereum Layer-2 network focused on bridging the gap between Web2 and Web3. Metis provides users with a decentralized and scalable easy-to-use network secured by Ethereum. Metis became the first Ethereum rollup to decentralize its sequencer with the launch of Decentralized Sequencer, which enhances network security, provides network ownership to node operators and allows more revenue earning opportunities for users. Metis.io | YouTube | Twitter | Reddit | Telegram | Telegram Announcement | Discord | Contact Details Colin Landers colin@energentmedia.com Company Website https://www.metis.io/

June 13, 2024 03:00 PM Eastern Daylight Time

News Direct Digest of Content Published on AffiliateAvenue June 1 -12

News Direct

The following content was published on AffiliateAvenue from June 1 – 12: Here's how much Americans have saved up in their retirement accounts by age — are you ahead or way behind? (Moneywise) Can You Guess How many Americans Successfully Retire with $1 Million Saved? The Percentage May Shock You. (Benzinga) The Best Bird Houses of 2024 (Amobeez) The Best Face Moisturizer with SPF of 2024 (Amobeez) The Best Lion's Mane Mushrooms of 2024 (Amobeez) 7 Best Plug-in Air Fresheners of 2024 (Amobeez) Best Hydration Mist Face Sprays of 2024 (Amobeez) Best Mini Blenders of 2024 (Amobeez) About Affiliate Avenue Affiliate Avenue is the newswire industry’s first and only affiliate marketing product that leverages the significant domain authority and traffic volume enjoyed by newsdirect.com to enable content marketing professionals and agencies to monetize content from in-demand market segments and categories. About News Direct News Direct is a technology-driven content distribution and amplification platform for PR, IR, corporate communications and marketing professionals. Our automated platform delivers a completely reimagined, modernized user experience for newswire users that has reshaped the industry landscape. Additionally, the company has expanded its offerings to include an array of technology-enhanced message amplification tools ranging from sponsored content to podcasting products, all from a single online destination. Contact Details News Direct Sales at News Direct +1 917-698-4131 sales@newsdirect.com Company Website http://www.newsdirect.com

June 13, 2024 01:45 PM Eastern Daylight Time

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Candel Therapeutics' (NASDAQ: CADL) enLIGHTEN Discovery Platform Aims To Tackle Complexities Of Tumor Microenvironments

The Biden administration just finalized a controversial new retirement rule — here are 5 things you need to know now

Elon Musk Boosts DOGE, Declares He Knows Dogwifhat. Raboo Surges 60%

Top Tax Question Answered by Republic Tax: Why Hire a Professional Tax Attorney to Eliminate IRS Tax Debt

Eliminating Tax Debts: How Existing IRS Policies Can Help

Combatting the Loneliness Epidemic: The Role of Muah AI in Providing Emotional Support

Crypto Market Update: How Galaxy Fox and Other Newcomers Are Shaping the Future of Online Gaming

Metis Introduces Governance Proposal for Liquid Staking Tokens (LST)

News Direct Digest of Content Published on AffiliateAvenue June 1 -12