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Classiq and AQT Partner to Deliver Seamless Ion-Trap Integration to Tackle Real-World Challenges

Classiq Technologies

Classiq Technologie s, a leader in quantum computing software, and Alpine Quantum Technologies (AQT), a global pioneer in ion-trap quantum computing, today announced a strategic partnership to deliver seamless integration between Classiq’s enterprise-grade quantum algorithm design platform and AQT’s state-of-the-art ion-trap quantum computers. By combining the Classiq platform’s ability to develop sophisticated, scalable quantum circuit implementations with AQT’s award-winning ion-trap hardware, the partnership offers customers expanded options for their quantum computing activities. It enables both enterprises and researchers to tackle complex computational challenges with greater efficiency. Through this partnership, users gain access to a unified workflow that bridges Classiq’s innovative, hardware-aware software tools with AQT’s advanced quantum hardware. Classiq’s platform automates the design, optimization and implementation of quantum algorithms, enabling users to develop, debug and execute sophisticated quantum applications. The integration with AQT’s precision ion-trap systems ensures high-performance operation, catering to the needs of enterprise teams and academic researchers alike. A Shared Vision for Quantum Innovation “We’re dedicated to offering our users the broadest set of quantum computing hardware options,” said Nir Minerbi, co-founder and CEO of Classiq. “The integration of our quantum algorithm design platform with AQT’s advanced ion-trap systems provides a compelling opportunity for enterprises and researchers to implement and run their quantum circuits with ease, scalability and reliability.” “This partnership brings together the best of quantum software and ion-trap hardware, allowing innovation to thrive,” said Dr. Thomas Monz, CEO of AQT. “By integrating with Classiq, we are making it simpler than ever for enterprises and researchers to harness the potential of ion-trap quantum computing for real-world challenges.” Building a Quantum Future This collaboration advances quantum readiness by fostering interoperability within the quantum ecosystem. By uniting their expertise in software and hardware, Classiq and AQT are paving the way for further innovation, benchmarking and the exploration of new quantum implementations. The partnership also opens doors for future collaboration opportunities, such as integrations with high-performance computing (HPC) environments. About Classiq Classiq Technologies, the leading quantum software company, provides an all-encompassing platform (IDE, compiler and OS) with a single point of entry into quantum computing, taking you from algorithm design to execution. The high-level descriptive quantum software development environment, tailored to all levels of developer proficiency, automates quantum programming. This ensures that a broad range of talents, including those with backgrounds in AI, ML and linear algebra, can harness quantum computing without requiring deep, specialized knowledge of quantum physics. Classiq democratizes access to quantum computing and equips its users to take full advantage of the quantum computing revolution, including access to a broad range of quantum hardware. Classiq’s core technology, algorithmic quantum circuit compilation, is engineered to power the quantum ecosystem of today and the future. Classiq works closely with quantum cloud providers and advanced computation hardware developers providing software for use with quantum computers, HPC and quantum simulators. Backed by investors such as HPE, HSBC, Samsung, Intesa Sanpaolo and NTT, Classiq’s world-class team of scientists and engineers has distilled decades of quantum expertise into its groundbreaking quantum engine. Follow Classiq on LinkedIn, X or YouTube, and visit the Slack community and www.classiq.io to learn more. About AQT Alpine Quantum Technologies (AQT) is a global leader in ion-trap quantum computing, offering high-fidelity systems designed for real-world scalability and applications. Based in Innsbruck, Austria, AQT builds on decades of academic excellence to provide industry-leading solutions for enterprise quantum computing. Follow AQT on LinkedIn and X. For more information about AQT, please visit: www.aqt.eu. Contact Details Rainier Communications Michelle Allard McMahon on behalf of Classiq classiqPR@rainierco.com AQT Franz Domig, Marketing & Communication Director +43 720 262627126 franz.domig@aqt.eu Company Website http://www.classiq.io/

December 05, 2024 08:00 AM Eastern Standard Time

YourFMO Enhances Agent ACA Marketplace Sales Experience

AmeriLife

YourFMO.com, a non-government agent resource site built for today’s valued health and life insurance agent, today announced the integration of Agility Insurance Services and its MyAdmin by Agility platform to support Affordable Care Act (ACA) plan sales. This exclusive offering is now available to YourFMO-contracted, licensed agents for the ACA Open Enrollment Period and beyond, with a comprehensive, real-time, and turnkey solution. As a result, this integration provides YourFMO-affiliated insurance agents with access to 20 contracted carriers offering ACA plans through a digitized process that eliminates paperwork, streamlines enrollments, and is designed to help increase productivity and efficiency. The platform serves as a one-stop shop, empowering agents to successfully manage their clients' ACA needs and track commissions seamlessly. "We are thrilled to integrate this innovative technology offered by Agility Insurance to enhance YourFMO’s comprehensive suite of agent resources," said JC Moreno, National Director of ACA at AmeriLife. "For ACA sales, this platform is a game-changer that simplifies enrollment and provides our agents with complete training guides powered by a robust CRM system." Agility Insurance Services offers its comprehensive platform for everything related to ACA sales. MyAdmin by Agility enables agents to manage client relationships, track interactions, and organize their sales efforts more effectively. This integration ensures that YourFMO contracted and licensed agents have all the necessary tools in one place, providing security and simplifying their workflow. Key features of this exclusive offering include: Digitization: Automates the enrollment experience, resulting in speed and efficiency. Real-time solutions: Instant access to plan details, quotes, and registration status. Turnkey solution: A single platform for everything ACA sales-related, from carrier plans to commission tracking. Comprehensive training: Complete guides to ensure agents are well-equipped to navigate the platform and ACA plans. YourFMO-affiliated agents can now leverage this powerful platform to better serve their clients and maximize their opportunities during the Open Enrollment Period and beyond. To sign up or learn more, please visit YourFMO.com. ### About YourFMO.com YourFMO is a non-government agent resource platform designed and managed by AmeriLife that is built to make selling insurance easy for our valued agents. YourFMO.com understands the need for the right technology, tools, and training for our independent agent partners to be successful in today’s health and life insurance marketplace. Contact us today to see how this suite of tools will benefit your business. For more information, visit YourFMO.com. About Agility Insurance Agility Insurance Services is an agency focused on equipping health insurance agents with all the tools they need to make health insurance available to anyone who might need it – from individuals to small business owners. Agility’s sales professionals specialize in health insurance marketing and contracting, and they provide ample resources to agents, ensuring their ability to better serve customers. Whether through assisting an individual or small business owners, Agility agents are dedicated to helping their customers find the best coverage possible. Learn more here. Contact Details YourFMO Jeff Maldonado media@yourfmo.com Luminos Creative Frank Vasquez fvasquez@luminoscreative.com Company Website https://amerilife.com/

December 03, 2024 10:30 AM Eastern Standard Time

AmeriLife’s Insurance Services Partners Acquires One Health Benefits

AmeriLife

Insurance Services, a family-run agency providing health, Medicare, and life insurance, and an affiliate of AmeriLife Group, LLC (“AmeriLife”), announced today that it has acquired One Health Benefits (“OHB”), a full-service independent insurance agency specializing in individual, group and senior insurance solutions. Per the agreement, terms of the deal were not disclosed. "We're excited to partner with One Health Benefits and its founder, Dena Schmid," said Chad Mikolajcik, principal of Insurance Services. "We’ve worked with Dena for many years and are continually impressed by her expertise and commitment to delivering exceptional service to her clients. Her passion and dedication align perfectly with our mission and AmeriLife's values, and we look forward to continuing to grow the company’s footprint and product solution offerings.” Through this partnership, Insurance Services gains a vital presence in South Carolina, allowing the company to serve its growing client base and ensuring that customers receive personalized and timely support for their health and life insurance needs. This strategic location enables Insurance Services to maintain OHB’s localized approach, strengthening the company’s market position and reinforcing its commitment to providing comprehensive and accessible health benefits to the residents of South Carolina. “Joining Insurance Services and AmeriLife's affiliate partnership program is a significant milestone for One Health Benefits," said Dena. "We look forward to the growth opportunities this acquisition presents and are eager to contribute our expertise to the Insurance Services team." As an affiliate partner of AmeriLife’s Health Distribution platform, OHB will access best-in-class platforms, tools, industry expertise, and an expansive product portfolio to move quickly into new markets, accelerate production, and drive the firm’s growth. "This partnership is another example of AmeriLife’s Health Distribution network continued growth," said Scotty Elliott, Chief Distribution Officer for AmeriLife Health. "With each strategic partnership, we enhance our ability to deliver innovative and comprehensive health and life insurance solutions, meeting consumer needs with unparalleled service and expertise." ### About Insurance Services Insurance Services is a leading provider of insurance solutions, offering various products and services to meet clients' unique needs. As a member of AmeriLife's affiliate partnership program, Insurance Services is committed to providing peace of mind and helping people live longer, healthier lives. For more information, visit MyInsuranceTeam.com. About One Health Benefits One Health Benefits is a full-service independent insurance agency specializing in Individual, Group, and Senior Insurance Solutions. We work with dozens of insurance companies so we can offer our clients appropriate coverage for them. Our clients are located across the United States, giving us an excellent feel for the insurance landscape. We design plans focusing on low costs and proper benefit structure, which we combine with personalized insurance advice aimed at helping our clients make better-informed decisions. For more information, visit OneHealthBenefits.com. About AmeriLife AmeriLife’s strength is its mission: to provide insurance and retirement solutions to help people live longer, healthier lives. In doing so, AmeriLife has become recognized as the leader in developing, marketing, and distributing life and health insurance, annuities, and retirement planning solutions to enhance the lives of pre-retirees and retirees across the United States. For over 50 years, AmeriLife has partnered with top insurance carriers to provide value and quality to customers through a distribution network of over 300,000 insurance agents, financial professionals, and over 160 marketing organizations and insurance agency locations nationwide. For more information, visit AmeriLife.com and follow AmeriLife on Facebook and LinkedIn. Contact Details Jeff Maldonado media@amerilife.com Partnership Inquiries Alex Hyer corporatedevelopment@amerilife.com Company Website https://amerilife.com/

December 03, 2024 09:00 AM Eastern Standard Time

Potential Opportunities In Cosmetic Healthcare Highlighted Through SBC Medical’s Story

Benzinga

By Gerelyn Terzo, Benzinga Cosmetic healthcare is no longer reserved for Hollywood elites. Rising demand has increased access to aesthetic surgery, as technological advancements have paved the way for innovative financing options and less invasive procedures – placing it within the grasp of a wider swath of the population. Meanwhile, the market opportunity is growing and expected to increase, placing the advantage in the hands of companies that have already gained the trust of their consumers – brands like Japan’s SBC Medical Group Holdings (NASDAQ: SBC). According to Research and Markets, the global market for cosmetic surgery will grow by double digits in 2024 to reach a size of $53 billion. Furthermore, it will continue to grow at a compound annual growth rate (CAGR) of 8.4% over 2024-2028 to culminate in a market size of $73.22 billion. In a recent report, McKinsey & Company predicted that the medical aesthetics sector, particularly in the United States and Canada, is here for the long haul and has demonstrated strong resilience in the face of changing economic cycles. The North American market growth is being fueled by demand for injectable procedures like Botox. According to the report, consumers continue to spend on cosmetic procedures, a heightened focus on cost-effective products and treatments notwithstanding. Demand is two-pronged, comprising a growing segment of the population who are most interested in the cosmetic benefits of self-care as well as those facing medical issues such as skin conditions in search of relief. Either way, the cosmetic healthcare industry seems poised for growth, and companies like SBC Medical Group are working hard to position themselves to continue to benefit from these macro trends. As a provider of comprehensive consulting and management services to medical corporations and their clinics, SBC Medical boasts the largest network of franchised clinics in Japan and a leading position in the aesthetic medical industry. The company’s revenue is growing as the number of clinics under its umbrella continues to expand. SBC Medical Group: A Case Study In Expansion In Aesthetics SBC Medical Group enjoys a dominant industry position in its home market of Japan, where it estimates it enjoys a 31% share of the market across hundreds of clinics. However, the company’s management team remains ambitious and has set its sights on expansion as SBC continues to take ground in cities like Irvine, CA and Ho Chi Minh City, Vietnam. Most recently, the company announced it has entered into a definitive agreement to acquire Aesthetic Healthcare Holdings Pte. Ltd. ("AHH"), a privately-held Singapore-based company that owns and operates several brands that provide aesthetic medical treatments, in an all-cash transaction. The acquisition by SBC of AHH marks the first step in the company’s strategy to grow its business through acquisitions, which includes plans to expand its business internationally with a primary focus on the U.S. and Asia markets. The company believes Singapore represents the ideal hub for the further development of its brand in the region. Furthermore, while the cosmetic surgery market is growing around the world, SBC Medical has managed to exceed the average growth rate. The company reports that its five-year revenue CAGR between 2018 and 2023 hovered at 24%, far outpacing the industry’s growth rate. SBC Medical attributes its growth largely to clinics that, under its leadership, are expanding their sales and customer base in Japan and beyond. The company benefits from a diversified revenue model in which it collects sales through different types of services, including management, procurement, rental and royalty income. While the market opportunity may already seem attractive, there may still be a growth story yet to unfold in the cosmetic healthcare market. For example, aesthetic medicine penetration among women up to their 30s in age is still increasing, fueled largely by demand for medical needs involving dermatology treatments. With total market penetration hovering at a modest 10%, as per estimates compiled by SBC, there is still plenty of room for further growth as the industry finds ways to reach middle-aged female and male patients whose ages range from 40 to 60. Cosmetic surgery among men has been growing as many search for cures like hair loss treatments and laser hair removal. To capture a potential windfall, SBC Medical is developing dermatology-focused services under its SBC brand and expanding laser hair removal to dermatology clinics via its Rise Clinics. While competition may be growing as more companies look to jump on the bandwagon, SBC Medical Group reports that it enjoys key advantages, not least its early-mover industry position. To maintain its lead, SBC is hyper-focused on growth, including expansions into adjacent medical fields such as treatments for fertility and hair loss, while it also looks to strike key business-to-business partnerships through which it can leverage complementary strengths. With an income statement comprising double-digit revenue growth, gross profit margin and operating profit margin, SBC Medical Group’s approach may already be paying off. Interested investors who are looking to add exposure to this market opportunity to their portfolios can learn more about SBC Medical’s stock on the company’s website sbc-holdings.com/en Featured photo by Adeolu Eletu on Unsplash. This post contains sponsored content. This content is for informational purposes only and is not intended to be investing advice. Benzinga is a leading financial media and data provider, known for delivering accurate, timely, and actionable financial information to empower investors and traders. Contact Details Benzinga +1 877-440-9464 info@benzinga.com Company Website http://www.benzinga.com

November 27, 2024 12:00 PM Eastern Standard Time

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Copperleaf Capital, LLC Partners with AmeriLife’s Brookstone Capital Management

AmeriLife

Brookstone Capital Management (“Brookstone”), a leading SEC-Registered Investment Advisory (RIA) firm and an affiliate of AmeriLife Group, LLC (“AmeriLife”), announced today that it has partnered with Copperleaf Capital, LLC, a financial planning firm and RIA based in Raleigh, North Carolina. Per the agreement, terms of the deal were not disclosed. "We're excited to join forces with Copperleaf Capital," said Dean Zayed, CEO of Brookstone Capital Management. "This partnership strengthens our organization and allows us to continue delivering best-in-class solutions for our clients. By combining our expertise, we're expanding our holistic approach to wealth management and ensuring our clients benefit from a comprehensive range of insurance and securities services.” “This collaboration underscores Brookstone's ongoing commitment to supporting our advisors and leading the way in integrated financial solutions,” added Darryl Ronconi, president of Brookstone Capital Management. “Together, we're better positioned to help clients navigate the complexities of wealth management and achieve their long-term financial goals." With over 35 years of experience, Copperleaf Capital has invested in positively impacting families through strategic wealth management and financial planning. Copperleaf Capital’s proprietary, step-by-step discovery and planning process identifies specific areas where families and individuals can make sound financial decisions, turning dream retirement scenarios into actionable deployment to reach each client’s retirement goals. "I couldn’t be more excited to partner and expand our relationship with Brookstone," said Ryan Peterson, president of Copperleaf Capital. "They are the best partner to take us to the next level. The entire team is thrilled about the opportunity of aligning Copperleaf Capital with the extensive resources and talent that they offer." As an affiliate partner of AmeriLife’s Wealth Distribution platform, Copperleaf Capital will enjoy broad access to best-in-class platforms, tools, resources, and an expansive product portfolio to move quickly into new markets, accelerate production, and drive the firm’s growth for years. "Ryan and his team have created a formidable brand and business transforming retirement planning for Americans planning for or entering their retirement years," said Mike Vietri, Chief Distribution Officer for AmeriLife Wealth Group. "We're thrilled to have Copperleaf Capital join forces with Brookstone under the AmeriLife Wealth Group umbrella. Their distinctive approach, expertise, and leadership will be invaluable as we expand and strengthen our dynamic and holistic distribution platform." About Brookstone Capital Management Founded in 2006, Brookstone Capital Management (BCM) is an SEC-Registered Investment Advisory firm with over $10B in Assets Under Management (AUM). It provides fee-based investment management services through its network of more than 750 financial advisors and firms. Brookstone is an innovator and industry leader and empowers independent financial advisors of all sizes to scale their business by providing access to a Turnkey Asset Management Platform (TAMP) and a dedicated team to support every aspect of an advisor’s practice. Visit BrookstoneCM.com for more information. About Copperleaf Capital, LLC Copperleaf creates retirement strategies using various investment and insurance products designed to meet the needs and objectives of its clients. Copperleaf Capital, LLC, a registered investment advisor, provides investment advisory services. Insurance products are offered separately through Copperleaf’s representatives in their capacity as licensed insurance agents. For more information, visit CopperleafCapital.com. About AmeriLife AmeriLife’s strength is its mission: to provide insurance and retirement solutions to help people live longer, healthier lives. In doing so, AmeriLife has become recognized as the leader in developing, marketing, and distributing life and health insurance, annuities, and retirement planning solutions to enhance the lives of pre-retirees and retirees across the United States. For over 50 years, AmeriLife has partnered with top insurance carriers to provide value and quality to customers through a distribution network of over 300,000 insurance agents, financial professionals, and over 160 marketing organizations and insurance agency locations nationwide. For more information, visit AmeriLife.com and follow AmeriLife on Facebook and LinkedIn. Contact Details Jeff Maldonado media@amerilife.com Partnership Inquiries Alex Hyer corporatedevelopment@amerilife.com Company Website https://amerilife.com/

November 25, 2024 09:00 AM Eastern Standard Time

Caregivers are the Heroes Among Us: Recognizing the Essential Role of Caregivers

YourUpdateTV

As our population ages, family health dynamics change, and healthcare complexities grow, the need for caregivers has never been greater. Yet, they often navigate their journeys in silence. In recognition of National Caregiver Month, Marvell Adams Jr., CEO of Caregiver Action Network, joined by caregiver Judy Krieg—who has cared for a loved one with Alzheimer’s disease— conducted a satellite media tour sponsored by Lundbeck and in conjunction with D S Simon Media. Together, Judy and Marvell shared insights on the caregiver journey and highlighted the " I Care " campaign, which celebrates the resilience and dedication of these remarkable individuals. A video accompanying this announcement is available at: https://youtu.be/pa5cw0kC55A In the U.S., more than half of those providing care don’t recognize themselves as caregivers. As a result, many do not access the tools that can alleviate caregiving stress. That’s why it’s important to help individuals identify themselves as caregivers and connect them with resources that can help make a difference. This year, during 2024 National Family Caregivers Month, Caregiver Action Network highlights the importance of self-recognition and self-identifying as a caregiver - key factors in caregivers’ access to essential support. Identifying as a caregiver opens the door to the family caregiver support needed throughout their journey. During this month, Caregiver Action Network also focuses on empowering caregivers and reminding them they are not alone in this journey. With the proper support and tools, one can continue to provide care while taking care of themselves. As Judy shares, she wishes she knew she wasn’t alone in the caregiver journey and had known more about symptoms of agitation associated with Alzheimer’s dementia. Resources to Share During 2024 National Family Caregivers Month There are many free resources available through the Caregiver Action Network to help those providing care navigate their caregiving journey: • Caregiver Help Desk – Access free, personalized support for your caregiving challenges. • 10 Tips for Family Caregivers – Learn practical strategies for managing caregiving stress. • Take Care of Your Mental Health – Use a free depression screener from the Caregiver Action Network to monitor your emotional well-being. • Connect with Other Family Caregivers – Join the Caregiver Action Network Community to share experiences and receive support. • Share Your Caregiver Story – Inspire others by sharing your caregiving journey. • Take Advantage of Resources from the I Care… Nonprofit Partners For more information, visit www.CaregiverAction.org ### BIO: Marvell Adams Marvell Adams Jr. is a highly skilled advocate, educator, and leader. He has a lifelong commitment to serving caregivers, marginalized communities, and older adults. After a nationwide search, the Board of Directors unanimously appointed Marvell as CEO of Caregiver Action Network. Marvell has shown dedication to serving caregivers since high school. He became fascinated with Alzheimer’s disease while completing a biology report. He pursued his education at the College of Charleston, earning a Bachelor of Arts in Political Science. Marvell later obtained a Master of Healthcare Administration specializing in Aging Services from the University of North Carolina – Chapel Hill. BIO: Judy Krieg Judy Krieg lives in Jackson, Michigan and assumed the role of caregiver for her parents when they began showing symptoms of Alzheimer’s disease (Mother) and Vascular Dementia (Father). Caring for two parents at once was physically and emotionally challenging. She became their Power of Attorney, attended medical appointments, moved them to assisted care and made them comfortable until they passed in 2020 and 2021. Judy’s mother displayed several agitation symptoms, including irritability, swearing, resisting help, and hoarding, and in addition she threatened suicide - making caregiving especially difficult. Despite an extensive career in pharmaceutical sales, focused on neuroscience, there was still a lot she didn’t know about being a caregiver. Judy is now a cheerleader and advocate for others who may be caring for a loved one and need support like she did. About CAN Caregiver Action Network (www.CaregiverAction.org) is the nation’s leading family caregiver organization working to improve the quality of life for more than 100 million Americans who care for loved ones with chronic conditions, disabilities, or diseases. CAN also supports those meeting the living needs of older adults. CAN serves a broad spectrum of family caregivers ranging from the parents of children with significant health needs. CAN (the National Family Caregivers Association) is a 501(c)(3) non-profit organization providing education, peer support, and resources to family caregivers across the country free of charge. About Lundbeck Lundbeck is a global biopharmaceutical company focusing exclusively on brain health. With more than 70 years of experience in neuroscience, they are committed to improving the lives of people with neurological and psychiatric diseases. As a focused innovator, they strive for our research and development programs to tackle some of the most complex neurological challenges. For additional information on Lundbeck US, please visit Lundbeck.com/us. About D S Simon Media The firm is well known as a leader in the satellite media tour industry and produces tours from its studio and multiple control rooms at its New York headquarters. Clients include top brands in healthcare, technology, travel, financial services, consumer goods, entertainment, retail and non-profits. Established in 1986, the firm has won more than 100 industry awards. Contact Details YourUpdateTV +1 212-736-2727 yourupdatetv@gmail.com

November 22, 2024 12:23 PM Eastern Standard Time

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Mainz Biomed Inks Major Deal To Develop A Next-Generation Cancer Test

Benzinga

By Johnny Rice, Benzinga Mainz Biomed NV (NASDAQ: MYNZ) announced a major new collaborative agreement with Thermo Fisher Scientific Inc. (NYSE: TMO) to jointly develop a next-generation colorectal cancer screening product. The partnership will combine Thermo Fisher's advanced technologies with Mainz Biomed's proprietary mRNA-based screening tests, which focus on early detection of colorectal cancer and precancerous lesions. Mainz CEO Guido Baechler highlighted the collaboration's potential to accelerate the development of a home collection screening tool with effective cancer detection. The collaboration will utilize Mainz Biomed's laboratories in Mainz, Germany, to leverage both companies' capabilities in developing advanced cancer screening technologies. Learn more here: This post contains sponsored content. This content is for informational purposes only and is not intended to be investing advice. Benzinga is a leading financial media and data provider, known for delivering accurate, timely, and actionable financial information to empower investors and traders. Contact Details Benzinga +1 877-440-9464 info@benzinga.com Company Website http://www.benzinga.com

November 22, 2024 09:30 AM Eastern Standard Time

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Turning Back The Clock On Aging: Telomir Pharmaceuticals Confirms Telomir-1 Reverses Age And Increased Longevity In Breakthrough Pre-Clinical Study

Benzinga

By Meg Flippin, Benzinga Turning back the clock on aging is the holy grail for the longevity industry, but is something that has proven elusive. That may be changing, thanks to companies like Telomir Pharmaceuticals Inc. (NASDAQ: TELO). The pre-clinical-stage company positioning itself as an emerging leader in age-reversal science is making inroads with Telomir-1, a compound designed to effectively turn back the biological clock and support longevity. Results from a preclinical trial confirmed the efficacy of the compound, reports Telomir. Using advanced in vivo microfluidic technology, in collaboration with Nagi Biosciences SA, the study demonstrated what Telomir said is significant age-reversal effects in aging model organisms treated with Telomir-1. These effects include an extended healthy lifespan, improved mobility and a measurable reversal of age-related decline. “The results we’re seeing with Telomir-1 mark an important step forward in our journey to potentially reverse aging in humans,” said Erez Aminov, Chairman and CEO of Telomir Pharmaceuticals in a press release announcing the trial results. “This study confirms that Telomir-1 can reverse biological aging, extending life while preserving health. We are very excited about the potential applications of Telomir-1 as we progress toward human clinical trials” Anti-Aging In A Compound Telomir-1 is focused on telomere regeneration which involves repairing telomeres or the DNA structures that protect the ends of our chromosomes, similar to caps on shoelaces. Numerous studies have shown fixing them can extend a person’s biological age and even turn back the clock on certain diseases. Telomir Pharmaceuticals says Telomir-1 is a novel small molecule to lengthen the DNA’s protective telomere caps in order to potentially reverse age-related conditions. The novel molecule, which Telomir is testing with mice and dogs with an eye toward human clinical trials, binds to critical metals that wear down telomeres. By limiting the availability of metals and interrupting the enzyme function, Telomir-1 seeks to restore cellular metal homeostasis and reverse a person's or animal’s biological age. The non-toxic oral therapy provides what the company says is a safe and effective alternative to existing treatments with minimal side effects. Telomir says Telomir-1 has the potential to impact patient care by offering new hope for managing and reversing age-related diseases and improving the quality of life for aging individuals. The Study Details The preclinical study, conducted in collaboration with Nagi Bioscience, utilized a sophisticated in vivo microfluidic-based assay to assess the effects of Telomir-1 on the nematode Caenorhabditis elegans, a well-established model for aging studies, reports Telomir. The microfluidic platform allowed precise, automated tracking of lifespan, healthspan and age-related mobility decline in real-time, enabling the research team to accurately measure the effects of Telomir-1 on these critical metrics. Two forms of Telomir-1 were administered in two concentrations. The study found that Telomir-1 significantly enhanced lifespan and healthspan parameters in aged microorganism populations. Some of the key findings include enhanced mobility in older organisms, reduced biological aging and increased lifespan. Subjects treated with Telomir-1 showed improved mobility, particularly in later stages of life compared to untreated controls. Telomir also said the study demonstrated “a measurable” reversal of biological age markers which the company said makes it a promising candidate for longevity treatments. What’s more, the company said Telomir-1 was associated with a statistically significant increase in lifespan among treated populations, further supporting Telomir-1’s role in promoting longevity. "At Nagi Bioscience, we are thrilled to contribute to this groundbreaking study through our innovative microfluidic technology, which allows precise and automated monitoring of aging and healthspan metrics in real-time,” said Dr. Laurent Mouchiroud, Chief Scientific Officer at Nagi Bioscience. “These results highlight Telomir-1’s remarkable potential to improve longevity and health, showcasing the power of cutting-edge tools in advancing age-reversal science." Expanding Telomir-1’s Reach Telomir sees many market opportunities for Telomir-1. There’s the longevity and anti-senescence therapy market, which is valued at $27.11 billion and is projected to reach $44.92 billion by 2031, growing at a CAGR of 6.8%. Then there’s Alzheimer's. Nearly seven million Americans suffer from this disease that attacks memory and cognitive functions. By 2050 that’s forecast to reach close to 13 million. And let's not forget cancer, another area Telomir-1 could prove effective in fighting. The global oncology market size is projected to reach $521.60 billion by 2033, growing at a CAGR of 8.9% from now until then. An additional area where Telomir-1 may help is in the treatment of progeria, a rare genetic disorder that causes accelerated aging in children. Telomir is intensifying its focus on the potential use of Telomir-1 to treat progeria and has engaged with the Progeria Foundation to investigate the effects of Telomir-1 on human progeria cell lines. This study will directly assess Telomir-1’s ability to counteract accelerated aging at the cellular level, offering critical insights into its therapeutic potential for progeria patients. Telomir also planned an in vivo study utilizing a progeria Caenorhabditis elegans model. This advanced microfluidic-based assay will evaluate Telomir-1’s impact on longevity, healthspan and biological aging in an organismal context. Telomir said these two studies represent a comprehensive approach to understanding Telomir-1’s effects on progeria, targeting both cellular and whole-organism models of the disease. On the canine front, Telomir is in talks with the North Carolina State College of Veterinary Medicine to establish a large-scale study on elderly dogs with osteoarthritis, further exploring Telomir-1’s potential to improve joint health and mobility. Turning back the clock on aging is the quest of many companies. Telomir believes it's getting closer to the successful formula. With the company all in with Telomir-1, stay tuned for more news on the trial front from this early-stage anti-aging innovator. Featured photo by JD Mason on Unsplash. Benzinga is a leading financial media and data provider, known for delivering accurate, timely, and actionable financial information to empower investors and traders. This post contains sponsored content. This content is for informational purposes only and is not intended to be investing advice. Contact Details Benzinga +1 877-440-9464 info@benzinga.com Company Website http://www.benzinga.com

November 22, 2024 09:00 AM Eastern Standard Time

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BioRestorative Ends Q3 In ‘Strong’ Financial Position, Reports Positive Data For Its Phase 2 BRTX-100 Chronic Back Pain Trial

Benzinga

By Meg Flippin, Benzinga BioRestorative Therapies, Inc. (NASDAQ: BRTX), a regenerative medicine company focused on stem cell-based therapies and products, is advancing toward profitability, narrowing its loss in the third quarter and releasing favorable data for its BRTX-100 treatment for chronic back pain. The third quarter was a busy period for BioRestorative, as it secured a new patent, released what it says is encouraging trial data and continued licensing discussions with a commercial-stage regenerative medicine company – while also reducing its losses. For the three months ending Sept. 30, 2024, BioRestorative posted an operating loss of $2.3 million, marking a 26% year-over-year improvement from $3.1 million in the same period last year. The net loss for the third quarter was $1.1 million, or $0.13 per share. BioRestorative said it ended the quarter in a “very strong financial position” with $13 million in cash and short-term investments. The company had no debt as of the end of the third quarter. “We have continued to execute well across all areas of our business and are looking forward to continuing to update investors on our progress as we close out the remainder of 2024,” says Lance Alstodt, BioRestorative’s chief executive officer. “From an operating perspective, we are thrilled with our third quarter results, as we are seeing initial progress on our path to sustainable profitability, driven by cost containment activities coupled with increased resources dedicated to our commercial programs.” Commercial Programs Making Inroads BioRestorative’s commercial programs got a boost late in the quarter when it announced it obtained a provisional license from the New York State Department of Health (NYSDOH) to process, isolate, expand and preserve allogeneic (non-autologous) donor tissue, including stem cells, for medical research. Previously BioRestorative was licensed by the NYSDOH to act as a tissue bank for the processing of mesenchymal stem cells derived from autologous donors only. “It will significantly enhance our ability to develop an unrivaled clinical pipeline of off-the-shelf cell-based biologic products,” says Alstodt. Meanwhile, the company’s product, ThermoStem®, which uses adipose-derived (brown fat) stem cells to generate new brown fat tissue to target obesity and metabolic disorders, drew attention during the quarter. BioRestorative shared details of the ThermoStem platform at IFATS 2024, the annual industry conference focused on adipose therapeutics and science. BioRestorative believes cell-based therapy candidates generated from its ThermoStem program may allow for lower dosing than GLP-1 obesity drugs or provide an alternative biologic-based treatment. Studies have shown brown fat activation in addition to weight loss, can lead to positive effects on several organs, including the heart, liver and muscle. The company competes with giants like Novo Nordisk (NYSE: NVO), Eli Lilly (NYSE: LLY) and Pfizer (NYSE: PFE) in the space. During the quarter, the Israel Patent Office issued the company a Notice of Allowance for a new patent application covering several fundamental aspects of ThermoStem. It's the 14th international patent. In addition to all that, BioRestorative continued talks for a ThermoStem licensing deal with an undisclosed commercial-stage regenerative medicine company. BRTX-100 Data Encouraging In conjunction with third-quarter earnings, BioRestorative released clinical data for BRTX-100, its autologous stem cell product for chronic lower back pain. It uses a patient’s stem cells, which are harvested, cultured and then injected directly into the affected disc to start the repair process. It’s targeted at the more than 25 million people in the U.S. who suffer from chronic lower back pain each year. Safety and efficacy endpoints from an ongoing phase 2 trial for the treatment of chronic lumbar disc disease (cLDD) were encouraging, BioRestorative reported. The company said no serious adverse events (SAEs) were reported in any of the 10 first patients of the prospective, randomized, double-blinded and controlled study. BioRestorative said there was also no dose limiting toxicity at 26-52 weeks. “Blinded preliminary clinical data of safety and efficacy endpoints from the ongoing phase 2 clinical trial of BRTX-100 in the treatment of cLDD are very encouraging, with patient-reported pain and function outcomes demonstrating a positive trend,” said Alstodt. “Most importantly, at 26 weeks, 70% of the patients are reporting a greater than 30% increase in function and a more than 30% decrease in pain. If data continues with this trend, we are confident that we will hit our efficacy endpoints for the phase 2 trial.” A total of up to 99 eligible subjects will be enrolled at up to 16 clinical sites in the United States. Subjects included in the trial will be randomized 2:1 to receive either BRTX-100 or a placebo. The new blinded preliminary safety and efficacy data from the ongoing phase 2 clinical trial of BRTX-100 was described in a podium presentation at the Orthopaedic Research Society (ORS) Philadelphia Spine Research Society (PSRS) 7th International Spine Research Symposium. From posting encouraging data to narrowing its losses, BioRestorative seems to be making strides on its path to profitability. With more news to come, this may be a story worth paying attention to. To learn more about BioRestorative’s stem cell therapies, click here. Featured photo by National Cancer Institute on Unsplash. Benzinga is a leading financial media and data provider, known for delivering accurate, timely, and actionable financial information to empower investors and traders. This post contains sponsored content. This content is for informational purposes only and is not intended to be investing advice. Contact Details Benzinga +1 877-440-9464 info@benzinga.com Company Website http://www.benzinga.com

November 21, 2024 08:45 AM Eastern Standard Time

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