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What Is Autologous Cell-Based Therapy, The Treatment Revolutionizing Regenerative Medicine That Could Be Set To Explode Over The Next Few Years?

BioRestorative Therapies, Inc.

By Julian Richard, Benzinga Successful Autologous Cell-Based Therapies The global CAR-T cell therapy market is growing continuously due to novel clinical and commercial developments in this therapy. As a result, the Global CAR-T cell therapy market is expected to be worth USD 4.36 billion by 2028 from 2.31 billion in 2023, growing with a healthy CAGR of 13.5% during the forecast period. Companies like Pfizer (NYSE: PFE) Johnson & Johnson (NYSE: JNJ, Bristol-Meyers Squibb (NYSE: BMY) as well as Gilead Sciences (NASDAQ: GILD) all are focusing on this innovative CAR-T cell therapy. Autologous cell based therapies are personalized therapies using your own cells to target a disease or disorder. Personalized therapies targeting cancer such CAR-T cell therapies have generated impressive clinical results with complete remission rates in B-acute lymphoblastic leukemia in over >80% of patients. One of the reasons this therapy has been successful is because it is autologous. In 2017, the U.S. FDA approved the first two CAR-T cell therapies: Novartis’ Kymriah ® for treatment of acute lymphoblastic leukemia (ALL) and Gilead subsidiary Kite Pharma’s Yescarta ® for certain types of large B-cell lymphomas, a type of non-Hodgkin lymphoma. These autologous therapies are patient-specific where the therapeutic CAR-T cells are created from a patient’s own cells. The Value of Autologous Stem-Cell Therapies Autologous stem-cell therapy is a novel medical technology that is revolutionizing the way the medical community approaches the treatment of metabolic, autoimmune and degenerative diseases. Additionally, this technique has been used successfully to develop skin grafts for wound care, treat burns and bedsores and speed up recovery after surgery. The method involves extracting stem cells from a patient’s body and culturing them in laboratory conditions before reintroducing them into the patient. Stem cells are a unique type of cell that can develop into any other cell in the body. These “supercharged” cells can be used for tissue regeneration and repair, making stem cells a potent tool in modern personalized medicine. Stratified medicine simply cannot compete with this customization, precision, and safety profile. The main benefit of using autologous cells is that these cells come from your own body and therefore do not trigger any immunological rejection reactions. They also minimize the risk of infection from non-patient sources. This allows autologous cell therapy to be used safely over a longer term, ensuring that the patient can access consistent and reliable treatment without risk of rejection or complications due to incompatibility. In 2021, the autologous cell therapy market was valued at $4.3 billion and was projected to skyrocket to $29.1 billion by 2031—marking a compounded annual growth rate (CAGR) of 21% from 2022-2031. Although the market is still nascent, it is expected to eventually create a new healthcare sector with revenue similar to that of the pharmaceutical, biotechnological, and medical devices industries. An Autologous Stem Cell-Based Approach to treat Disc Pain BioRestorative Therapies Inc (NASDAQ: BRTX) focuses on innovative “home-grown” autologous stem-cell therapies to address unmet needs in patients with common yet serious diseases. It was founded by medical doctors, scientists and world-renowned stem-cell researchers committed to developing novel stem-cell therapies. The lead candidate in BioRestorative’s musculoskeletal stem-cell platform is BRTX-100, administered as a minimally-invasive single intradiscal injection. BRTX-100 is currently being evaluated in an FDA gold standard phase 2 double-blind, controlled, randomized study in those with chronic lumbar disc disease (cLDD). Chronic lumbar disc disease affects over 500 million individuals globally and is currently only treatable with opioids and surgery. Despite being the most commonly prescribed drug for cLLD, no clinical data supports the use of opioids in cLLD, which only serves to increase the opioid crisis in the USA. Surgery for cLLD carries many disadvantages and limitations. The cost of surgery can be high. While surgical intervention may reduce pain in some cases, it often fails to restore previous levels of function or mobility. Revision or reoperation rates for surgical intervention in the spine can be upwards of 20-30% of the cases performed. Furthermore, a more extended recovery period is associated with an increased risk of mechanical instability of the spine and potentially increased failure rates compared to non-surgical treatments. It would appear a bright future awaits BioRestorative Therapies and the autologous cell therapy market in general as patients increasingly look at personalized alternatives to surgery and conventional medicine. BRTX-100 is an innovative and minimally-invasive technology set to revolutionize lower back pain treatment. Visit https://www.biorestorative.com for more information on the company and its product candidates. This article was originally published on Benzinga here. BioRestorative Therapies was founded by scientists and researchers committed to developing stem cell therapies to address unmet needs in patients with highly prevalent conditions.Our advances in stem cell biology and delivery protocols harbor great promise in conditioning our bodies’ own regenerative potential to treat major diseases more effectively than current interventions.Today, BioRestorative is actively developing programs that aim to dramatically increase quality of care for both (i) chronic back pain caused by disc degeneration, as well as (ii) metabolic disorders including obesity and diabetes. This post contains sponsored advertising content. This content is for informational purposes only and is not intended to be investing advice. Contact Details Investor Relations ir@biorestorative.com Company Website https://www.biorestorative.com/

March 22, 2023 09:15 AM Eastern Daylight Time

Global Wellness Company Fine Hygienic Holding Launches eon Longevity, an All-Natural Herbal Longevity Supplement

Fine Hygienic Holding

Fine Hygienic Holding (FHH), one of the world’s leading wellness groups, today announced the launch of eon ™, a powdered, herbal beverage supplement that supports overall health and longevity. Comprising an all-natural, proprietary herbal blend, eon Longevity +Plus (eon’s signature product) underwent one of the largest clinical studies in the supplement space. The results verified that eon supports the health of the cardiovascular, respiratory, and gastrointestinal systems; regulates normal metabolic balance; and helps reduce inflammation — all of which result in a healthier and stronger body. One of the most impactful findings is eon’s ability to reduce inflammation, which is a breakthrough since inflammation is at the core of most, if not all, diseases in the human body. “With these outstanding clinical results, it can be argued that eon could be the healthiest beverage a person can consume and should be part of everyone’s personal wellness program to improve quality of life and even life expectancy,” said Medical Wellness Association (MWA) President Dr. Christopher Breuleux, who underwrote the clinical study. “We are a company devoted to improving people’s health and lives by providing reliable, tested, high-quality products,” said eon Founder and FHH President of Wellness Elia G. Nuqul. “We are extremely happy to finally make this amazing product available after more than 3.5 years of hard work. The biggest reward in all this is knowing we have something that can really improve people’s health and lives, and unlock their longevity at an affordable price.” eon is the first FHH product to be fully procured, manufactured, packaged and launched in the U.S. The beverage supplement has also been professionally certified by the MWA. FHH CEO James Michael Lafferty said, “eon reduces total body inflammation, resulting in significant health benefits. You will not find a modern drug using these powerful ingredients to battle inflammation, which is often linked to conditions such as cancer, heart disease, diabetes, asthma, and Alzheimer's disease.” Inspired by Tea from the Mediterranean The inspiration behind eon’s innovation came from a viral video viewed by Lafferty and Nuqul. It featured a centenarian man youthfully navigating his village, climbing trees, and attributing his long and healthy life to his herbal tea. Captivated by this video, Nuqul embarked on an international sojourn to locate the elder gentleman and learn directly about the drink that kept him so spry. After studying, modifying, and enhancing the tea with the MWA, eon is the result. “eon is a beautiful marriage of nature and science. The ingredients of this beverage supplement have been tested independently and proven to have significant health benefits, most notably in the battle of inflammation and the systemic problems it causes,” added Lafferty. “Here was this centenarian living a healthy and full life attributed to drinking this drink, so we asked ourselves: What if the root to longevity is in the Mediterranean — and what if this benefit was available to everyone for the same price as a cup of coffee?” Clinical Study Results The clinical study, underwritten by the Medical Wellness Association, was one of the largest ever in the wellness supplement industry. Each participant consumed the beverage daily, all under medical supervision. The clinical trials scientifically proved, with statistical significance, that the consumption of eon Longevity +Plus yielded a range of health benefits, including: Reduces and controls inflammation and pain, a breakthrough since inflammation is at the core of most, if not all, diseases in the human body Supports cardiovascular and respiratory health Powerful source of antioxidants Regulates normal metabolic syndrome and improves gastrointestinal (gut) health Improves kidney and liver function (*amongst a subset of the clinical study) Reduces pre-diabetes risk factors Reduces stress Improves mood, vitality and sleep eon Now Available In addition to the clinically proven eon Longevity +Plus (which includes the highly bioavailable curcumin), customers also have access to eon Longevity, which is the all-natural herbal proprietary blend inspired by the centenarian man (without the curcumin). For best results, consume either blend at least once daily mixed with warm or cold water on an empty stomach. It may also be added to other beverages such as coffee or tea. The beverage supplement is only available as individual stick packs online at www.eon-longevity.com. About eonThe eon Longevity Blends™ are all-natural, herbal beverage supplements inspired by a generations-old formula and created by nature. Through one of the largest clinical studies conducted in the supplement space, eon Longevity +Plus (eon’s signature product) has been scientifically proven to provide significant health benefits when consumed at least once a day, especially through the reduction of inflammation. eon is part of Fine Hygienic Holding, one of the world’s leading wellness groups. More at www.eon-longevity.com. About Fine Hygienic HoldingFine Hygienic Holding (FHH), one of the world’s leading wellness groups and MENA’s leading manufacturer of hygienic products, serves consumers in more than 80 countries around the world. Originally established as a paper manufacturer, FHH has transformed into a wellness company dedicated to enhancing global health and wellbeing. Committed to becoming “the shining star of the Arab FMCG business world,” the Group focuses on wellness, sustainability, pioneering CSR programs, and state-of-the-art production processes. Fine Hygienic Holding offers a diverse array of award-winning products, including sterilized facial tissues, napkins, kitchen towels, toilet paper, baby diapers, adult briefs, jumbo rolls. It also offers away-from-home products to accommodate all types of private and public institutions in addition to its advanced range of personal protective equipment and long-lasting germ protection solutions. FHH also brings Nai natural iced teas and innovative nutritional supplements, such as eon and Motiva, to the market. Contact Details Rana Kawalit | │ Corporate Communication & PR Director +971 54 531 5575 Rkawalit@finehh.com Company Website https://www.finehh.com/

March 21, 2023 05:20 PM Eastern Daylight Time

Traveling on a Budget in 2023

YourUpdateTV

While prices for flights, hotels and rental cars are all up across the board, demand for travel isn’t slowing. A recent survey from pay over time provider, Affirm, revealed that despite record-high costs, the average person plans to take three trips this year and spend over $3,000 on travel. Furthermore, 3 in 4 of Millennial and Gen-Z respondents plan to take up to 6 trips this year, with over half planning to spend up to $5,000 on travel. Traveling on a budget can help ensure that people are spending responsibly while also providing ways to make their money go further. Affirm SVP and Financial Health Expert, Katrina Holt, participated in a nationwide satellite media tour, offering her top tips for financially-conscious travelers in 2023: Don’t forget to set a budget. The recent Affirm survey found that nearly 1 in 5 plan to travel this year without setting a budget beforehand, which can easily lead to overspending. When creating a budget, be sure to consider expenses across accommodation, meals, transportation and shopping. Use a transparent, flexible pay over time option like Affirm to spread out your costs and stick to your budget. By selecting Affirm at checkout, approved travelers can split travel costs into biweekly or monthly payments. Travelers will see the total cost of their purchase and will never pay more than they agree to upfront Affirm does not charge late or hidden fees. Watch out for gimmicks that come with travel credit cards. Early sign up bonuses might be enticing, but can easily lead to overspending as you try to hit the minimum. 0% APR credit card promotions can come with deferred interest and surprise you with balloon payments down the line. A video accompanying this announcement is available at: https://youtu.be/2ZCQtGXL7y8 Affirm is helping travelers by offering a smarter way to pay at some of the largest travel merchants in the US and Canada, including American Airlines, Expedia, Hotels.com, KAYAK, Vrbo, Priceline, and more. For more information, visit Affirm.com About Katrina Holt Katrina Holt is the SVP, Operations and Financial Health Expert at Affirm. Affirm is a new kind of payment network — one based on trust, transparency and putting people first. As a technology and financial services executive, Katrina brings more than 27 years of financial services, operations, and risk management leadership. Prior to Affirm, she was the Chief Compliance Officer at GE Capital Bank and WebBank, respectively. Earlier in her career, Katrina served as the Audit Director for GE Capital, as well as a commissioned bank examiner with the FDIC. She holds an Executive MBA from the University of Utah and a BS in Accounting from Weber State University. Contact Details YourUpdateTV +1 212-736-2727 yourupdatetv@gmail.com

March 21, 2023 02:30 PM Eastern Daylight Time

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Colorado pet owners say yes, they want access to mid-level veterinary professionals and telehealth

Vet Care Coalition

Responding to increasing costs and unavailability due to the state’s significant veterinary workforce shortage, four out of five Colorado pet owners say they would not hesitate to have their animal seen by a newly-created mid-level veterinary professional associate, similar in function and oversight to a physician assistant (PA). These are among the findings of an independent survey of Colorado pet owners announced by the Vet Care Coalition (VetCareCoalition.com), an expanding alliance of animal welfare organizations, veterinarians and technicians, pet owners, ranchers and other experts working to establish workable solutions to the state’s costly veterinary workforce shortage. The Vet Care Coalition is pursuing legislation in Colorado’s statehouse to achieve three common-sense initiatives toward addressing the state’s veterinary shortage: 1. Establishing a path for creation of a mid-level veterinary professional associate (VPA), similar to a physician assistant (PA) in human medicine. A VPA will be a master’s degree-level professional working under the supervision of a veterinarian to provide care such as examining pets, diagnosing minor conditions, performing routine surgeries and leading healthcare teams. These professionals will generate practice revenue while increasing overall workforce capacity, helping to increase patient availability while lowering costs. 2. Codifying the availability of veterinary care through telehealth services, which are increasingly used in human medicine. More than half of the state’s pet owners surveyed said they would be comfortable using virtual veterinary care for their animals. 3. Expanding the role of registered veterinarian technician specialists (VTS), with additional training and credentialing. “Vet tech” specialists are often underutilized in veterinary practices because Colorado regulations unreasonably limit what they can legally do. Expanding the role of a VTS will increase veterinary care capacity across the state while helping encourage retention at a time when many are leaving the sector due to burn-out and lack of professional growth. Colorado’s veterinary shortage is well-documented In 2021, the U.S. Department of Agriculture identified 25 rural and urban Colorado counties as having “veterinary shortage situations” in food animal medicine – a situation that contributes to higher prices while putting food safety at risk. In addition, the Veterinary Care Accessibility Project (AccessToVetCare.org) gave Colorado a score of only 58 out of 100, noting that veterinary care is nearly inaccessible in much of the state. The shortage has had a negative impact on pet owners and their animals across the country – and could get much worse. A Mars Veterinary Health study found that without solutions put in place soon, the U.S. will have 15,000 fewer veterinarians than it needs by 2030, leaving some 75 million pets without any veterinary care at all. The Colorado survey, conducted in mid-January by Corona Insights research firm, asked 556 pet owners across the state how they have been impacted by the veterinary shortage and gauged their initial comfort level with being seen by a VPA or via telehealth services. The research found that high veterinary costs generate the greatest level of concern and dissatisfaction among pet owners, with almost 25 percent saying high costs made them decide against taking their animals in for necessary care over the last year. The U.S. Dept. of Labor Consumer Price Index shows that between 1997 and 2022, veterinarian services steadily rose at almost twice the rate of inflation. Through 2021 and 2022 alone, the nation’s veterinary shortage contributed to service prices increasing by more than 13 percent. More than a quarter of survey respondents also said they were significantly challenged in finding and making timely appointments with veterinarians in their area. Logical and urgent need for a mid-level veterinary professional “While the human medical profession has embraced physician assistants for more than 50 years, veterinary medicine inexplicably still has no such mid-level professional position,” said coalition spokesperson Dr. Apryl Steele, past president of the Colorado Veterinary Medical Association (CVMA) and current CEO of the Dumb Friends League. “Animals will suffer until we fill this glaring need,” said Dr. Steele, “while Colorado’s veterinary workforce will continue to be severely overworked and understaffed.” The American Medical Association (AMA) officially recognized physician assistants in 1971, with the first PA certification tests implemented by the National Board of Medical Examiners two years later. “The VPA would not replace a veterinarian or a veterinary technician,” said Dr. Steele. “Rather, it will enhance a practice while providing credentialed veterinary technicians with a career path toward greater responsibility and compensation.” In Colorado’s USDA-identified veterinary shortage areas, VPAs will be allowed to work under indirect supervision to help increase access to care for food and fiber animals. “It’s important to understand that fully utilizing veterinary technicians and creating a mid-level veterinary PA are complementary options for solving Colorado’s veterinarian workforce shortage crisis,” said Dr. Steele. “We absolutely need both.” About the Vet Care Coalition The Vet Care Coalition is an expanding alliance that includes animal welfare organizations, veterinarians and technicians, pet owners, ranchers and other experts with a common goal to find workable solutions to the state’s costly veterinary workforce shortage. Organizational coalition members supporting the legislation include the Animal Welfare Association of Colorado (AWAC), Colorado Voters for Animals, the Dumb Friends League (DFL), Thrive Pet Healthcare, Humane Society of the Pikes Peak Region (HSPPR), Roice-Hurst Humane Society, Virtual Veterinary Care Association, Animal Policy Group, WellHaven Pet Health, Larimer Humane Society, the American Society for the Prevention of Cruelty to Animals (ASPCA) and Mars Petcare. Individual supporters include four former presidents of the Colorado Veterinary Medical Association (CVMA), as well as a growing number of veterinarians, practice owners and animal welfare advocates across the nation. For more information and to support efforts to increase access to veterinary care across Colorado, please visit www.vetcarecoalition.com. Contact Details Vet Care Coalition Steven Silvers +1 720-402-8820 ssilvers@vetcarecoalition.com

March 21, 2023 08:50 AM Mountain Daylight Time

Aqua Cultured Foods to Begin Consumer Tastings of Alt-Seafood

AquaCultured Foods

Food tech startup Aqua Cultured Foods today announced it will begin consumer tastings of its seafood alternatives at its Chicago facility in advance of launching publicly through chef partners and foodservice distributors. Aqua will offer participants Aqua tuna rolls, shrimp dumplings and scallop crudo, and solicit feedback. Tastings will be held in Aqua’s West Loop, Chicago headquarters beginning in early April. Aqua is developing a range of alt-seafood from proprietary mycoprotein fermentation processes. A unique strain of fungi transforms plant-based ingredients into “seafood” with a realistic taste, texture, and appearance that can be used as a one-to-one replacement for animal seafood. The company is also producing minced fillings for applications such as dumplings, ravioli, and sushi rolls. “Public tasting events will help us fine-tune products and learn what preparations are most successful, which will also help us create new menu items with chef and restaurant partners,” said Aqua CEO Anne Palermo. “Participants should arrive hungry and prepare to be wowed, because they’ve never had plant-based seafood that’s this delicious and this convincing.” Those interested in joining a tasting panel can sign up at https://www.eventbrite.com/e/aqua-customer-taste-panels-tickets-565576212677?aff=Newsletter. Aqua’s calamari, shrimp, scallops, and filets of tuna and whitefish are created using fermentation processes that do not use any animal inputs, genetic altering or modification. Unlike plant-based processed foods formulated with starches and protein isolates, Aqua’s alt-seafood retains its naturally occurring fiber, protein, and other micronutrients. The rising demand for seafood has led to depleted fish populations, ecosystem damage, plastic waste, and unintended “bycatch” of non-target species due to commercial fishing. As fish farming increases, so does habitat destruction, pollution and diseases in wild fish populations, and the industry’s reliance on antibiotics and wild-caught fish for feed. For images visit https://app.box.com/s/wfbrvgraf2ty2b7by5h6ahjsaqrd8zx3. About Aqua Cultured Foods Aqua Cultured Foods is an innovative food technology startup developing the world’s first whole-muscle cut seafood alternatives created through microbial fermentation. Its novel technology produces a sustainable, complete protein source using only a fraction of the resources required by traditional aquaculture. As the first to develop realistic alt-seafood with fermentation, Aqua Cultured Foods occupies a unique position in the burgeoning alt-seafood market, as well as within the fermentation industry. The company’s mission is to mitigate global challenges such as overfishing, climate change and feeding the world’s expanding population with delicious, nutrient-rich foods. For more information visit https://www.aquaculturedfoods.com. Contact Details Evolotus PR Gary Smith +1 818-783-0569 gary@evolotuspr.com Company Website https://www.aquaculturedfoods.com

March 21, 2023 09:30 AM Eastern Daylight Time

Axis Medicare Advisors Partners with AmeriLife to Accelerate Growth

AmeriLife

AmeriLife Group, LLC (“AmeriLife”), a national leader in developing, marketing, and distributing life and health insurance, annuities and retirement planning solutions, announced today that it has partnered with Louisville, Ky.-based Axis Medicare Advisors, one of the nation’s top designers and distributors of market-leading Medicare Supplement and ancillary health products for Aetna. Per the agreement, terms of the deal were not disclosed. “Our business was built on ‘trust,’ and today, I’m excited to announce that we, too, have found a trusted partner in AmeriLife to propel Axis forward,” said James “Jamie” Sarno, president and CEO of Axis Medicare Advisors. “Our team is excited to join this industry leader. We look forward to tapping into AmeriLife’s incredible leadership and resources to continue delivering excellence for Axis agents and their clients.” Founded in 1991, Axis has grown from a small outfit into a leading Medicare solutions shop known for its deep Medicare Supplement and ancillary health product portfolio, best-in-class customer service, and expert knowledge of the evolving and complex Medicare space. Now, Axis will have full access to AmeriLife’s best-in-class technology, tools and resources and leading distribution platform, positioning it for significant growth and long-term success. Relatedly, Sarno will join AmeriLife as vice president of Medicare Supplement and Specialty Health and will report to AmeriLife’s Chief Distribution Officer of Health, Scotty Elliott, effective April 3. Sarno brings over 35 years of experience in the Medicare Supplement market to AmeriLife, and as a national advisor for Aetna, he has supported the design of proprietary products that remain core to AmeriLife’s holistic health offering. With Sarno’s departure, Ronnie Lapinsky will assume day-to-day operational oversight of Axis. “Ronnie has been a loyal friend and valuable asset at Axis for more than 21 years,” added Sarno. “There’s no one better suited to continue Axis’s legacy of protecting seniors and helping them with the ever-changing landscape of Medicare.” “We’re thrilled to welcome Axis Medicare Advisors to AmeriLife’s Health family and, at the same time, Jamie to our growing Health leadership bench,” said Elliott. “Both represent the continued, incredible run of growth for our Health distribution. We can’t wait to work with Jamie to elevate our Medicare Supplement and health specialty strategy while also helping Ronnie and his team at Axis expand and grow their business to new heights.” ### About AmeriLife AmeriLife’s strength is its mission: to provide insurance and retirement solutions to help people live longer, healthier lives. In doing so, AmeriLife has become recognized as the leader in developing, marketing, and distributing life and health insurance, annuities and retirement planning solutions to enhance the lives of pre-retirees and retirees across the United States. For more than 50 years, AmeriLife has partnered with top insurance carriers to provide value and quality to customers served through a distribution network of over 300,000 insurance agents and advisors and 120 marketing organizations and insurance agency locations nationwide. For more information, visit AmeriLife.com, and follow AmeriLife on Facebook and LinkedIn. About Axis Medicare Advisors Founded in 1991 and based in Louisville, Ky., Axis Medicare Advisors is a leading Medicare and specialty health insurance agency serving seniors nationwide. Axis’s team of professionals offers unparalleled customer support, expert advice and a portfolio of health solutions from some of the biggest insurance carriers in the market. For more information, visit AxisMedicareAdvisors.com. Contact Details Media Jeff Maldonado +1 321-297-1112 jmaldonado@amerilife.com Partnership Inquiries Patrick Nichols +1 727-726-0726 pnichols@amerilife.com Company Website https://amerilife.com/

March 21, 2023 09:00 AM Eastern Daylight Time

Greene Concepts Secures New Retail Distribution to Five Hundred Grocery Stores

Greene Concepts, Inc.

McapMediaWire - - Greene Concepts, Inc. (OTC: INKW) is pleased to announce it has finalized a retail and distribution agreement with Merchants Distributors (MDI) and Lowes Foods. Both entities will shelf and carry BE WATER’s TM new six-pack configurations throughout the Eastern U.S. with a reach of nearly 500 grocery outlets. Distribution to the new retailers occurs March through late-April. The agreement includes 400 independent stores covered by MDI and 80+ Lowes Foods Stores throughout the region. 380 of the 650 MDI stores will utilize BE WATER planograms, a schematic tool used to plan a retail store layout. Planograms place special attention on product placement and displays, as well as point-of-sale locations. Brian Adkins, Greene Concepts Sales Consultant, notes, “We have worked aggressively to achieve the first large-scale grocery distribution deal for BE WATER. MDI and Lowes Foods are fantastic partners and I am very pleased that they see the value in bringing on our BE WATER six-packs. It takes time to secure retail relationships and share with distributors and retailers the benefits of BE WATER and its appeal to consumers. We have been able to secure both accounts resulting in the aggressive movement of BE WATER production and distribution. This is a significant step forward for us all.” Brian Adkins continues, “We have almost tripled Greene Concepts’ footprint of BE WATER throughout the country to bring the total store count of BE WATER to over 800 stores nationally. The availability of six-packs increases the entry point for consumers to purchase BE WATER at a reduced cost. Because of MDI and Lowes Foods, BE WATER will be seen and purchased by a larger audience before the end of April and I could not be happier for the company, our customers, and especially for Greene Concepts shareholders. Thank you for continuing to believe in us and in our progression together.” Lenny Greene, CEO of Greene Concepts, states, “The timing of these new distribution and retail deals coincides with the release of our new six-pack configuration which passed our sample tests and will come off the line in full production and begin reaching MDI and Lowes Foods stores in March with availability at each of their locations by the end of April. We are thrilled to have our BE WATER product line reach new audiences while vastly increasing our revenues and product reach. I would like to give a special thanks to Brian for making this happen and am blessed to have him as part of the Greene Concepts team. I also thank MDI, Lowes Foods, and their parent company Alex Lee for trusting us as a premium beverage supplier.” Follow Greene Concepts Inc. on Twitter as well as BE WATER TM Submit investor questions to IR@greeneconcepts.com About Merchants Distributors (MDI), LLC Merchants Distributors (MDI) is a privately-owned wholesale grocery store distributor headquartered in Hickory, NC. MDI supplies over 600 retail food stores with food and non-food items in 12 Eastern states to include NC, SC, GA, TN, VA, AL, WV, OH, FL, PA, MD, and KY. MDI has been supplying retail supermarkets for over 90 years. In addition to full-service distribution to supermarkets in 12 East Coast states, MDI offers cold storage to manufacturers, provides digital services for retail, has a large format print facility, and exports to over 30 countries. The company has a strong customer focus and offers a variety of services to help their customers succeed. https://www.mdi.com/ About Lowes Foods, LLC Founded in 1954, Lowes Foods employs nearly 9,000 people and operates more than 80 full-service supermarkets in the Carolinas with an annual revenue of $1.6 billion. Locally owned and operated, Lowes Foods is truly a homegrown company committed to bringing community back to the table, by providing customers with the freshest and most innovative local products from local suppliers. Lowes Foods operates independently while purchasing through MDI for their distribution. This also includes several Just$ave stores. To learn more, visit https://www.lowesfoods.com / or follow Lowes Foods on Facebook or Twitter. Lowes Foods, LLC is a wholly-owned subsidiary of Alex Lee, Inc. About Alex Lee, Inc. Founded in 1931, Alex Lee is a family-owned and operated company that employs nearly 10,000 people. It serves as the parent company of Merchants Distributors, LLC, which provides full-service, wholesale distribution to supermarkets across the Southeastern United States. In addition, Alex Lee is the parent company of Lowes Foods as well as Just$ave food stores in North Carolina. Alex Lee, Inc. is based in Hickory, NC. For more information, please visit https://www.alexlee.com. About Greene Concepts, Inc. Greene Concepts, Inc. ( http://www.greeneconcepts.com ) is a publicly traded company whose purpose is to provide the world with high-quality, healthy and enhanced beverage choices that meet the nutritional needs of its consumers while refreshing their mind, body and spirit. The Company’s flagship product, BE WATER, is a premium artesian bottled water that supports total body health and wellness. Greene Concepts’ beverage and bottling plant is located in Marion, North Carolina, and their water is ethically sourced from seven spring and artesian wells that are fed from a natural aquifer located deep beneath the Blue Ridge Mountains. Greene Concepts continues to develop and market premium beverage brands designed to enhance the daily lives of consumers. Safe Harbor: This Press Release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. These forward-looking statements are based on the current plans and expectations of management and are subject to a few uncertainties and risks that could significantly affect the company's current plans and expectations, as well as future results of operations and financial condition. A more extensive listing of risks and factors that may affect the company's business prospects and cause actual results to differ materially from those described in the forward-looking statements can be found in the reports and other documents filed by the company with the Securities and Exchange Commission and OTC Markets, Inc. OTC Disclosure and News Service. The company undertakes no obligation to publicly update or revise any forward-looking statements, because of new information, future events or otherwise. CONTACT: Greene Concepts, Inc. Investor Relations IR@greeneconcepts.com Contact Details Greene Concepts, Inc. IR@greeneconcepts.com Company Website https://greeneconcepts.com/

March 21, 2023 08:45 AM Eastern Daylight Time

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Angie Avers Shares Why She Left Corporate World to Buy & Grow Minuteman Press Franchise in Phoenix, AZ

Minuteman Press International Inc

Angie Avers has owned her Minuteman Press franchise in Phoenix, Arizona since July of 2021. In this interview, Angie shares how she no longer felt valued as an employee working for others, why she felt comfortable taking the leap into business ownership with Minuteman Press, and how she has successfully grown her business. Angie’s Minuteman Press center is located at 2432 W. Peoria Ave., Suite 1023, Phoenix, AZ 85029. What does it mean to you to be a business owner? Why did you choose Minuteman Press? Angie Avers: “I left the corporate environment after nearly 30 years because I was tired of working for someone else and not feeling valued as an employee. I also struggled with finding a new job for over 2 years as well. One day on LinkedIn, the Minuteman Press opportunity presented itself and I inquired about it. I thought to myself, I have nothing to lose at this point so why not? I was later contacted by Brady Rockwell from the Minuteman Press Int’l team and it all started to become real. I started to panic and almost walked away from this opportunity, but after looking at what Minuteman Press International has accomplished and what they were about, I was sold! I knew they wouldn’t judge me for my age or my background and the key part of it all was ‘we’ll train you.’ My background is in marketing and communications, and why wouldn’t I want to help other business owners build their business with print and promotional products? I thought “this is a no brainer!” What has the support from Minuteman Press International been like for you? Angie Avers: “Minuteman support has been great. Whenever I have a problem with FLEX the team always helps me and if I have other issues, I’m always directed to the correct person. There is so much information in FLEX that I still would like to learn even more. Jack Panzer, my local RVP in Arizona, and Sky Hittle, our Field Rep, are always there to help and be there for when I need help or they direct me to where I need to be.” What do you think sets you apart from the competition? Angie Avers: “I describe my business as a ‘full-service print and marketing design company exclusively ran by women.’ We have a plethora of resources at our fingertips and if we can’t do it in-house, we always have resources to help. I believe what sets us apart is our strong work ethic, our honesty with our customers, and our customer service.” What are your high-demand products and key growth areas? Angie Avers: “It’s really hard to say what our high-demand products are. Our core is still paper products, but we are growing other areas. One area we have grown substantially is our design services. New business owners come into our shop all the time. We discuss what their initial needs are and we start with their logo and colors. From there, we build upon what their other needs are and help them brand other products they may need for their business. One customer comes to mind, where we started from scratch with their logo, then brochures and flyers, labels, and now trade show equipment and promotional products. It’s been super fun helping them build their brand and grow their business.” What are some of the key ways you’ve grown your business? Angie Avers: “One of the biggest ways I grew my business was through an acquisition and it doubled my business last year. I also network with BNI and other organizations when I have a chance. I have started doing more email marketing now that my learning curve has minimized some. Our foot traffic into the shop has also grown. When I took over the business, we put up all new window graphics and added two 14-ft. flags in front of the shop which is located on a main road. We have customers tell us all the time they saw our flags outside.” Why do you think printing remains so vital to businesses today? Angie Avers: “Print is vital because without it, everything would just be shapes and images. A world cannot go without print. We wouldn’t even know how to read if we didn’t have print. So, it is vital for sure.” What are the biggest personal and professional rewards of owning your business? Angie Avers: “Personally, I like answering to myself and making myself accountable for what is happening in my business. I thrive on giving my all to our customers and having a team that gets the job done without me chasing after them all the time. My goal is to be a million-dollar shop before I retire and professionally speaking, I just love helping businesses in my community come alive and building those relationships to sell other products.” What advice would you give to other business owners right now? Angie Avers: “Do your research, put together your pros and cons on being a business owner, and while it’s scary to take the plunge, you’ll never know unless you try. Change is hard for a lot of people, but you don’t grow staying in the same place where you are unhappy. Challenge yourself to be the best you. I did and it was the best decision I ever made. I love what I’m doing, and I wouldn’t change it for anything.” Angie Avers’ Minuteman Press franchise is located at 2432 W. Peoria Ave., Suite 1023, Phoenix, AZ 85029. For more information, call or visit their website: https://minuteman.com/us/locations/az/phoenix20/ Learn more about #1 rated Minuteman Press franchise opportunities and read Minuteman Press franchise reviews at https://minutemanpressfranchise.com Contact Details Minuteman Press International Chris Biscuiti +1 631-249-1370 cbiscuiti@mpihq.com Company Website https://minutemanpressfranchise.com

March 20, 2023 10:00 AM Eastern Daylight Time

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From Releasing A Public Course On Using ChatGPT To Leveraging The AI To Improve Company Efficiency — Amesite (NASDAQ: AMST) Looks Ahead Of The Curve For Integrating ChatGPT

Amesite Inc.

By David Willey, Benzinga Click here to read the latest report on Amesite Inc. ChatGPT has shown the potential changes that generative artificial intelligence can bring to the market. Amesite Inc. (NASDAQ: AMST), a Detroit-based AI software company, has set out the progress it has made in integrating generative AI into its platform. The release of ChatGPT showcased the capabilities and potential of generative AI, which is able to produce increasingly sophisticated original content. The Everything as a Service (XaaS) market, which includes products like generative AI, is predicted to reach $1.2 trillion by 2031 growing at a compound annual growth rate of 23.4% between 2021 and 2031, according to a study from Spherical Insights & Consulting. Unsurprisingly, investing in AI capabilities remains a top priority for businesses as they look for new ways to harness innovations in AI technology. For companies like Amestie that also have exposure to the e-learning market, there could be additonal opportunities to merge growth in both, with the overall global e-learning market projected to climb to nearly $1 trillion by 2028. A lot of uncertainty remains, however, around strategies for systematically integrating generative AI and systems like ChatGPT’s language model, GPT-3. The education sector in particular has shown an unwillingness to adopt the technology, with at least one school district blocking the program’s website, and universities holding internal meetings to discuss how to control the impact of ChatGPT. Amesite, on the other hand, has always had an AI-first strategy. Founded in 2018 to provide a platform and content for the best upskilling and e-learning opportunities, Amesite’s approach has allowed the platform to quickly pivot to integrate the latest AI technology into its system. Amesite Shareholder Presentation Amesite Chief Executive Officer (CEO) Anne Marie Sastry recently shared an update for shareholders over a call. In it, she discussed the company’s financial position, as well as the steps the company has taken to integrate GPT-3 into its platform and business model. Sastry reported that Amesite has had an increase in both its revenue and sales pipeline over the past four quarters and that the company has seen an overall increase in operational efficiency in the same time period. She identified the integration of generative AI into the coding and business operations as a key factor in driving the efficiency and outreach gains made by the company. Sastry made a series of Amesite stock purchases in February and March 2023, buying a total of 6,000 shares of common stock in the company for a purchase price of $16,800. This means Sastry, who has never sold any of her common stock shares in Amesite, now owns over 531,000 shares. This kind of insider buying, where a CEO purchases company stock, generally indicates optimism by company executives about the future growth and stock value of a company. Leveraging AI Developments Sastry commented during the shareholder update on how Amesite is keeping up with the fast-paced developments in the AI industry. As part of its generative AI offerings, Amesite launched new learning and creative assistants that help course designers create content for the platform. It also released a publicly available course on the fundamentals of using ChatGPT. According to Sastry’s presentation, the announcement of Amesite’s ChatGPT content resulted in a five times increase in site traffic. Amesite continues to host eLearning and upskilling programs that have a 99% learner retention rate for businesses, non-profits, and institutes of higher education. Amesite recently announced a pilot program in partnership with Benedict College, as part of the company’s alliance with the National Association for Equal Opportunity in Higher Education (NAFEO). The Benedict College Pilot is an upskilling program that gives students the skills to thrive in a tech-driven economy. "Benedict’s commitment to their students is admirable, and Amesite is proud to be able to provide them with a scalable online infrastructure and technology upskilling content to enable them to deliver this learning with excellence. This pilot is another example of how we can deliver much-needed upskilling campus-wide, very efficiently," said Dr. Ann Marie Sastry, Founder and CEO of Amesite. Other companies in the online learning space include Coursera Inc. (NYSE: COUR), 2U (NASDAQ: TWOU) and Powerschool Holdings Inc. (NYSE: PWSC). Interested in learning more about Amesite? Visit its website. This article was originally published on Benzinga here. Amesite Inc., an artificial intelligence driven platform and course designer, provides online products in the United States. The company uses machine learning to offer a mass customized experience to learners. Its customers include businesses, universities and colleges, K-12 schools, and non-profit organizations. The company was incorporated in 2017 and is headquartered in Detroit, Michigan. This post contains sponsored advertising content. This content is for informational purposes only and not intended to be investing advice. Contact Details Amesite, Inc. +1 734-876-8141 info@amesite.com Company Website http://www.amesite.io

March 20, 2023 09:30 AM Eastern Daylight Time

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