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Elicio Therapeutics (NASDAQ: ELTX) Reports Promising Progress In Cancer Vaccine Clinical Trials, Placing An Emphasis On The Lymphatic System

Benzinga

By Jeremy Golden, Benzinga An estimated 609,820 people will die of cancer in the United States this year, according to the National Cancer Institute. Promising results from a 12-year-old clinical-stage biotechnology company have experts optimistic about the future of treating this deadly disease. With its proprietary Amphiphile or “AMP” platform, Elicio Therapeutics Inc. (NASDAQ: ELTX) has developed multiple cancer vaccine candidates that concentrate an array of different immunogens in the lymph nodes. ELI-002 is Elicio’s lead clinical program for Kirsten rat sarcoma (KRAS) driven cancers caused by a mutation of the KRAS gene. An “off the shelf” approach designed to stimulate an immune response against the seven KRAS mutations driving 25% of solid tumors, ELI-002 is currently being studied in AMPLIFY-201 – a phase 1 dose escalation study – and AMPLIFY-7P, a phase 1/2 study. In September, Elicio released new information about the vaccine candidates in its pipeline at the ninth AACR Special Conference on Pancreatic Cancer in Boston. The positive preliminary relapse-free survival (RFS) data from the ongoing AMPLIFY-201 study demonstrated an 86% reduction in risk of progression or death in patients with large T-cell responses induced by ELI-002 2P, a 2-peptide formulation designed to treat cancers driven by G12D and G12R mutations in KRAS. Despite the AMPLIYF-201 study not including a control arm, the median RFS of over 16 months is significantly longer than what has been seen in other studies of similar patient groups. “Patients with mutant KRAS cancers, particularly pancreatic and colorectal cancers, have a poor prognosis with limited treatment options when tumor DNA or protein biomarkers are detected after standard surgery and chemotherapy,” said Eileen M. O’Reilly, M.D., Winthrop Rockefeller Endowed Chair of Medical Oncology and Co-Director of Medical Initiatives at David M. Rubenstein Center for Pancreatic Cancer Research. “We are encouraged by the early data showing ELI-002 induced T cells can positively impact clinical endpoints including the risk of relapse and death in this study.” Targeting Immunogens To Lymph Nodes Elicio has demonstrated preclinically that Amphiphiles target and concentrate an array of different immunogens in the lymph nodes, which are located throughout the body on the lymphatic vessels at various intervals along the lymphatic routes. During the process of circulating throughout the lymphatic system, lymph fluid accumulates antigens and other biomolecules captured from the tissues. This fluid then drains into the lymph nodes, where it encounters T cells and B cells congregating together with antigen-presenting cells (APCs). Targeting the immunogens in the lymph nodes has been proven to result in tumor or pathogen-targeted immunity, including potent T cell and humoral responses, in preclinical trials. Alongside AMPLIFY-201, ELI-002 7P is currently being studied in AMPLIFY-7P, a phase 1/2 trial in patients with high relapse risk mKRAS-driven solid tumors. Designed to provide immune response coverage against seven of the most common KRAS mutations, the ELI-002 7P formulation increases the potential patient population for ELI-002 while possibly reducing the chance of bypassing resistance mechanisms. Moving forward in early 2024, Elicio Therapeutics plans to initiate a randomized phase 2 trial studying ELI-002 7P as a monotherapy in adjuvant PDAC patients. This post contains sponsored content. This content is for informational purposes only and is not intended to be investing advice. Contact Details Benzinga +1 877-440-9464 info@benzinga.com Company Website http://www.benzinga.com

November 03, 2023 09:00 AM Eastern Daylight Time

Preparing for Mexico’s TIIE Transition: Lessons from LIBOR

Tradeweb

The clock is ticking louder on the transition to a new overnight funding rate benchmark for Mexico’s $4.9 trillion swaps market. As we shared in our recent post, Mexico’s TIIE-28 Benchmark is About to Go the Way of LIBOR; Are You Ready?, the Tasa de Interés Interbancaria de Equilibrio, or Interbank Equilibrium Interest Rate (TIIE) will gradually move to a new standard, the TIIE de Fondeo (F-TIIE), starting on January 1, 2024. While many market participants have already begun making the transition and others are busy hammering out their plans, there is still no discernable liquidity benchmarked to the new standard and many questions remain about how, exactly, the marketplace will respond when the switch is flipped next year. Fortunately, we’ve been through this before, and many of the lessons learned over the course of the recent LIBOR migration are also applicable to F-TIIE. Best Practices for a Smooth Transition As a hub of swaps trading activity, Tradeweb played a central role in the transition from LIBOR to the Secured Overnight Financing Rate (SOFR). Now we are working with our clients and Banco de México to share insights and advice on how to navigate the challenges that will inevitably accompany the TIIE transition. We’ve identified several best practices for market participants to prepare for the fast-approaching deadlines, which are January 2024 and January 2025. Collaboration is Key: LIBOR earned its reputation as “the world’s most important number” over the course of a 30-year run, during which it became the interest rate benchmark for hundreds of trillions of dollars of financial instruments globally. Transitioning away from that standard created countless valuation, trade processing and settlement details that needed to be sorted. But it’s important to note that the transition was made possible through close collaboration, including between market participants and regulators who coordinated efforts ahead of target deadlines and communicated frequently. That same spirit of collaboration is already present in the F-TIIE transition, as various stakeholders have been working together to drive a successful outcome. Expect Bumps in the Road: Tradeweb conducted several analyses tracking liquidity in the swaps market throughout the LIBOR transition, monitoring trades benchmarked to LIBOR and those benchmarked to the new SOFR standard over several different time periods. One of our most interesting observations surrounded the July 26, 2021 “SOFR First” phased initiative, where we saw the implied cost of liquidity—as measured by bid-offer spreads—gradually tighten in the weeks and months leading up to the July 26 announcement, then subsequently tighten further. The lesson learned here was that while there was a premium on liquidity using the new benchmark for a short time, but that premium soon faded once the marketplace migrated to the new standard. Benchmark Transitions Happen Gradually, Then All at Once: Another lesson learned in the LIBOR transition was that, although many firms had already done the heavy lifting on preparing themselves to use the new benchmark, the actual adoption was gradual. In fact, the percentage of new U.S. dollar swaps trades benchmarked to SOFR and executed on the Tradeweb platform did not start to trend upward until August of 2021. From there, SOFR adoption grew slowly but steadily until it surged in January 2022 aligned with the regulatory deadline for no new LIBOR origination. The key takeaway here is that even though it may look like many firms have not yet made the conversion, most are in the process of getting ready and will be able to do so when the deadline hits. Electronification Helps: As was the case with LIBOR, the TIIE transition can be made easier for those trading electronically. Obvious benefits like direct integration with order management systems and built-in audit trail for clearing and settlement help to streamline the process. In addition, more advanced capabilities that are only available on electronic markets, such as trade compression tools -- which allow market participants to easily collapse old positions and roll them into a new index in a single transaction -- can ease the process of getting old positions onto the new benchmark. How We’re Helping Fortunately there are plenty of resources and opportunities available to market participants right now to prepare for the transition. One example is Tradeweb’s collaboration with the Banco de México who together in mid-November will convene stakeholders, including clearinghouses, dealers and the investor community to discuss key deadlines, transition strategies and navigating challenges. As we continue to observe and learn best practices from these market participants, we will continue to provide updates here to share what we’ve learned. About Tradeweb Markets Tradeweb Markets Inc. (Nasdaq: TW) is a leading, global operator of electronic marketplaces for rates, credit, equities and money markets. Founded in 1996, Tradeweb provides access to markets, data and analytics, electronic trading, straight-through-processing and reporting for more than 40 products to clients in the institutional, wholesale and retail markets. Advanced technologies developed by Tradeweb enhance price discovery, order execution and trade workflows while allowing for greater scale and helping to reduce risks in client trading operations. Tradeweb serves more than 2,500 clients in more than 65 countries. On average, Tradeweb facilitated more than $1.2 trillion in notional value traded per day over the past four quarters. For more information, please go to www.tradeweb.com. Forward-Looking Statements This release contains forward-looking statements within the meaning of the federal securities laws. Statements related to, among other things, our outlook and future performance, the industry and markets in which we operate, our expectations, beliefs, plans, strategies, objectives, prospects and assumptions and future events are forward-looking statements. We have based these forward-looking statements on our current expectations, assumptions, estimates and projections. While we believe these expectations, assumptions, estimates and projections are reasonable, such forward-looking statements are only predictions and involve known and unknown risks and uncertainties, many of which are beyond our control. These and other important factors, including those discussed under the heading “Risk Factors” in documents of Tradeweb Markets Inc. on file with or furnished to the SEC, may cause our actual results, performance or achievements to differ materially from those expressed or implied by these forward-looking statements. Given these risks and uncertainties, you are cautioned not to place undue reliance on such forward-looking statements. The forward-looking statements contained in this release are not guarantees of future performance and our actual results of operations, financial condition or liquidity, and the development of the industry and markets in which we operate, may differ materially from the forward-looking statements contained in this release. In addition, even if our results of operations, financial condition or liquidity, and events in the industry and markets in which we operate, are consistent with the forward-looking statements contained in this release, they may not be predictive of results or developments in future periods. Any forward-looking statement that we make in this release speaks only as of the date of such statement. Except as required by law, we do not undertake any obligation to update or revise, or to publicly announce any update or revision to, any of the forward-looking statements, whether as a result of new information, future events or otherwise, after the date of this release. Contact Details Daniel Noonan +1 646-767-4677 Daniel.Noonan@Tradeweb.com Company Website http://www.tradeweb.com

November 02, 2023 05:08 PM Eastern Daylight Time

News Release

RDARS CEO says innovative autonomous drone security system is likely to take flight in 2024

RDARS

RDARS Inc. president and CEO Charles Zwebner tells Proactive's Stephen Gunnion the company is preparing for a large scaling up of sales of its innovative autonomous drone security system in 2024 after the company commenced commercialization in June 2023. The CSE-listed company has already started selling the Drone Eagle Watch Platforms as it continues to advance the technology. Discussions are also underway with various large security companies for potential joint ventures. The system consists of a drone nest and the drone itself, designed for security and surveillance purposes. It is equipped to autonomously respond to security breaches on a property, flying predetermined missions or manual interventions, and transmitting live data to a command center. The company is targeting residential, commercial, industrial, and government clients seeking enhanced security and surveillance capabilities. After receiving its first 'Beyond Line of Site' waiver from the US Federal Aviation Administration (FAA), Zwebner said the company continues to engage with the FAA to obtain a criteria blanket waiver, expected in 2024, which will enable it to scale up sales. Contact Details Proactive Investors +1 604-688-8158 na-editorial@proactiveinvestors.com

November 02, 2023 02:48 PM Eastern Daylight Time

Video

QuickNode Releases The On-Chain Report Q3: Stablecoins Hit 400K Daily Active Addresses

QuickNode

QuickNode, an end-to-end development platform for Web3 innovation, has released The On-Chain Report to highlight the developments in the blockchain industry in the third quarter of 2023. Prepared with Artemis, an institutional data platform for digital assets, The On-Chain Report provides a comprehensive overview of blockchain usage and investments in Q3 by examining consumer trends, developer activity and the investment landscape. Among the key findings of The On-Chain Report is the significant increase in stablecoin activity across blockchain networks. Stablecoins have become the most popular category as measured by daily active addresses (DAA), ending Q3 with over 400,000 average DAA. Stablecoin has also become the only category examined by the report that has shown growth in Q3 2023, outperforming DeFi, Social, Gaming and NFT categories Key takeaways from QuickNode’s On-Chain Report include: Consumer activity was dominated by financial activity, with stablecoin activity taking the crown from DeFi. Fueled primarily by the Friend.tech trend, DeSocial is starting to emerge with viral product launches. The potential for a Web2 scale social app will turn the current adoption levels on its head. Development activity remains strong only on Optimism’s OP Mainnet, suggesting that developers see EVM scaling solutions as a critical problem to solve in the near term. Future trends, as informed by investment data, suggest that gaming and AI offerings are where the blockchain ecosystem will see the greatest emergence in the coming years. Commenting on the report, QuickNode Co-founder and CEO, Dmitry Shklovsky said: “By centering the narrative around blockchain developers and end users, we gain valuable insights into the roadmap for building a sustainable and rapidly expanding Web3 ecosystem. These insights, combined with the context of product launches and investments, give us a comprehensive story of where we're heading.” Prepared by QuickNode and Artemis, The On-Chain Report draws an insightful picture of the blockchain industry by looking at today, medium term and long term. The report offers detailed stats and analyses categorized by Stablecoins, DeFi, NFT, Social dApps and EVM-scaling Solutions. To prepare the report, QuickNode has examined the average daily value on a weekly basis on Arbitrum One, Avalanche, Base, BNB Chain, Ethereum, OP Mainnet and Polygon PoS, using Artemis.xyz as the primary data source. The On-Chain Report is available here. About QuickNode Since its founding in 2017, QuickNode has emerged as the go-to solution for businesses and innovators requiring world-class blockchain development tools for speed, reliability, and security. Handling over eight billion blockchain requests daily, QuickNode boasts a 2.5X faster response time than competitors and 99.99% uptime across 24+ chains and 35+ networks. With a user-friendly interface and a robust multi-chain developer tool suite, QuickNode is an ideal choice for top Web3 businesses and global brands. About Artemis Since launching in 2022, Artemis has emerged as a premier institutional data platform for digital assets. Delivering insights across 25+ blockchains, Artemis stands out as the definitive data science layer for crypto fundamental information. From sector-specific metrics to real-time developer engagement insights, Artemis ensures that users are equipped with the most comprehensive and customizable digital asset data available. With its wide availability of data ingestion choices, from Excel integrations to Snowflake Data Shares, Artemis is the data platform of choice for global financial institutions and investors. Contact Details MarketAcross PR Kim Bazak Kim@marketacross.com Company Website https://www.quicknode.com/

November 02, 2023 02:00 PM Eastern Daylight Time

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PathAI Announces New NASH/MASH Advisory Network to Guide Evidence Generation and Regulatory Strategy for AI-Powered Digital Pathology Product Development

PathAI

PathAI, a leading provider of precision pathology solutions, today announced the formation of a new advisory network to inform the company’s vision to leverage AI-powered digital pathology to improve outcomes for individuals with non-alcoholic steatohepatitis/metabolic dysfunction-associated steatohepatitis (NASH/MASH). According to the American Liver Foundation, approximately 2-5% of adults in the U.S. have NASH/MASH, a disease with no FDA-approved treatments currently available. Disease incidence has risen from 1.51% in 2010 to 2.79% in 2020. The American Liver Foundation predicts that by 2030, NASH/MASH will be the most frequent reason for liver transplants in the U.S., underscoring the severe impact of this disease. Given the burden of NASH/MASH and lack of available treatment options for patients, attention from industry and academia alike is increasing, with numerous clinical trials in progress to develop novel, efficacious therapies for patients. PathAI has worked closely with experts in the field of NASH/MASH for years, including leading researchers, academics, patient advocacy groups, regulatory bodies and biotechnology and pharma partners, contributing to the development of solutions for this challenging disease. Previously, this close collaboration with NASH/MASH subject matter experts led to the development and validation of AIM-NASH ™, a tool that promises to reduce the impact of pathologist scoring variability on clinical trial outcomes by assisting pathologists in grading and staging key histologic features of NASH/MASH 1,2,as well as NASH Explore ™, an AI-powered panel of more than 1000 quantitative Human Interpretable Features (HIFs) that spatially characterize NASH/MASH tissue biopsy microarchitecture at the zonal and cellular level from H&E whole slide images. Now, PathAI will build on that collaboration by bringing together a diverse group of stakeholders across academia, medicine, regulatory science, patient advocacy, and industry to inform the evolution of the company portfolio. The network’s first meeting was held in September and will be held quarterly moving forward. “Scoring liver biopsies by an expert pathologist is a crucial aspect of NASH/MASH clinical trials. However, this benchmark tool is limited both in the availability of liver pathologists and intra/inter-observer variability of their evaluation,” Pierre Bedossa, Professor of Pathology at Groupe Hospitalier Paris Nord and visiting professor at the Institute of Cellular Medicine at Newcastle University, and PathAI advisor, pointed out. “AIM-NASH developed by PathAI marks clearly a step forward. This tool alleviates some of the limitations by providing a trustworthy AI-based evaluation of liver biopsy functioning under pathologist supervision. Promising results of AIM-NASH in the context of NASH clinical trials strongly suggest that this tool may become essential to speed up drug evaluation and development for the benefit of patients.” Other members of the advisor network include: Stephen A. Harrison, medical director for Pinnacle Clinical Research and the president of Summit Clinical Research. Karoline Lackner, professor of pathology at the Medical University of Graz. Rohit Loomba, professor of medicine and director of hepatology at the University of California at San Diego. Romil Saxena, professor of pathology and laboratory medicine at Emory University School of Medicine and a diplomate of the American Board of Pathology. G. Mani Subramanian, founder, OrsoBio Chris Leptak, Senior Vice President; drugs and biologics at Greenleaf Health, Inc. “As a leader in digital pathology for liver diseases, we recognize the responsibility we have to advance the science towards effective treatments for NASH/MASH with cutting-edge technology,” said Andy Beck, MD, PhD, co-founder and CEO of PathAI. “At the same time, we recognize that only by incorporating the ideas and expertise of the leading minds in MASH will we truly achieve our mutual goal of improving patient outcomes for MASH patients.” The PathAI team will be attending the American Association for the Study of Liver Diseases annual meeting November 10-14 in Boston. Schedule time to talk about how PathAI’s solutions can drive liver disease clinical development at our booth (# D3100) by emailing nash@pathai.com. Read more about PathAI’s robust AI-powered products for NASH, including AIM-NASH ™ and NASH Explore ™, on PathAI’s website. 1 Harrison et al., Retrospective AI-based Measurement of NASH Histology (AIM-NASH) Analysis of Biopsies From Phase 2 Study of Resmetirom Confirms Significant Treatment-induced Changes in Histologic Features of Nonalcoholic Steatohepatitis, EASL poster 2022. 2 Shevell et al. Comparison of manual vs machine learning approaches to liver biopsy scoring for NASH and fibrosis: a post hoc analysis of the FALCON 1 study. AASLD poster 2021 AIM-NASH & NASH Explore are authorized for research use only. Not approved for diagnostic use. About PathAI PathAI is a recognized leader in the biopharma partnering space, uniquely combining AI-powered pathology solutions with end-to-end central pathology and histology services. The company supports biopharma partners in executing clinical trials where pathology-based endpoints, biomarker classification, and/or superior histology quality are critical to successfully gauging therapeutic efficacy, accelerating drug development for complex diseases. PathAI has already supported multiple Phase 2 clinical trials in NASH, IBD, and breast cancer, as well as oncology neoadjuvant trials, and is now expanding into larger scale global Phase 3 studies, as well as additional indications. PathAI provides a fully integrated approach to clinical trials, enabling pharma partners to leverage the power of AI without the heavy lift of implementation. This helps reduce the impact of challenges associated with clinical trials, including unreliable turnaround times, variable histology, stain or scan/digitization quality, and challenging assessment of histological endpoints. The lab offers all major immunohistochemistry staining platforms, with flexible workflows across different scanners, stains, and biopsy types, which improves the quality of clinical trials. Services include access to PathAI’s extensive network of over 500 US Board Certified pathologists to perform high quality reading with rapid turnaround time in a cost-effective manner, plus seamless integration of PathAI's advanced AI-solutions to ensure high-quality, reproducible results with every scan. PathAI is headquartered in Boston, MA, and operates its CAP/CLIA-certified diagnostics clinical laboratory (formerly known as Poplar Healthcare) – one of the country’s largest anatomic pathology labs – in Memphis, TN. For more information, please visit www.pathai.com Contact Details SVM Public Relations and Marketing Communications Maggie Naples +1 401-490-9700 pathai@svmpr.com Company Website https://www.pathai.com/

November 02, 2023 10:00 AM Eastern Daylight Time

Dashtoon secures $5M to bring comic creation to the masses

Dashtoon

The advent of text-to-image AI diffusion models uncovered a promising opportunity for the digital comics landscape, akin to the transformative impact of high-quality camera phones and the rise of platforms like Instagram and TikTok. Now, Dashtoon is on a mission to make this cutting-edge technology accessible to storytellers worldwide, aiming to democratize the creation of digital comics and empower creators across the globe with its Dashtoon AI Studio and Dashtoon Comic Reader Apps. Today, Dashtoon is announcing a $5 million seed funding led by Matrix Partners India and Stellaris Venture Partners with participation from prominent angel investors. San Francisco and London-based Dashtoon was founded in December 2022 by Sanidhya Narain, Lalith Gudipati, and Soumyadeep Mukherjee. Lalith and Sanidhya were both part of the founding team of audio entertainment startup Pocket FM and were instrumental in building and growing the product in the US. Soumyadeep has built and scaled deep-tech teams at various startups including solving for cancer diagnosis at Morphle Labs. A vibrant creator economy for the comics ecosystem exists in markets like Japan and Southeast Asia but not so much in the other parts of the world. Consequently, Japanese Manga and Korean Webtoons have now ascended to the forefront, asserting their dominance over the global comics market while nurturing billion-dollar IPs - replicated into multiple formats like games, movies, TV series, etc. Beyond storytelling, till now, comic creation required hard skills like sketching, coloring, lettering, etc., thus creating an entry barrier for this medium. The current creator ecosystems were built over decades, and it wasn’t possible to replicate them in other parts of the world. But now, with Dashtoon, any storyteller, from published author to aspiring writer, in any part of the world, can effortlessly create, distribute, and monetize their comics and graphic novels - the age of democratization. "Content businesses have largely capitalized on technology for distribution. We at Dashtoon believe it's time to bring that technological edge to content creation itself. Generative AI will not only level the playing field for storytellers worldwide but will also meet the diverse tastes of global consumers.” says Sanidhya Narain, CEO and Co-founder of Dashtoon. Dashtoon Studio, the first of its kind, guarantees unparalleled character consistency, fine control over image composition, and streamlined comic creation workflows. This state-of-the-art platform provides creators access to an extensive character library and the capability to train and monetize their unique characters, enabling the production of professional-quality, engaging content ready for global consumption. “With Dashtoon Studio, any storyteller, regardless of their artistic skills or technical knowledge, can create digital comics, breaking traditional barriers in illustrated content creation. Our vision is to become a global IP powerhouse by marrying thousands of creators with millions of readers,” says Soumyadeep Mukherjee, CTO and Co-founder. For example, a creator can upload their storyboard on Dashtoon Studio, select characters for each panel, and generate images with deterministic and consistent output in a few minutes. The creator can use smart AI editing capabilities in the studio to edit the generated output. What used to take 40-50 hours to create an episode can currently be done in 5-6 hours, thus allowing creators to publish a new episode daily on Dashtoon Comic Reader apps. With further advancement, Dashtoon will add multi-modal capabilities to generate storyboards and dialogues using AI, further reducing the creation time of an episode to less than an hour. Dashtoon Studio is a valuable tool that complements the creative process, empowering creators to unleash their imagination and craft compelling narratives without being bogged down by repetitive, time-consuming tasks. A synergy between technology and creativity paves the way for innovative storytelling and content creation. Dashtoon Comic Reader Apps are a cornerstone for writers desiring to broaden their horizons, offering an invaluable opportunity to penetrate the thriving comics market. For consumers - this means that they do not have to wait weeks for new episodes of their favorite comics - with the increase in content creation speed, they get new episodes daily on Dashtoon Comic Reader. Due to non-existent native creator ecosystems - consumers were mostly limited in choices to consume Japanese manga or Korean webtoons, but now they will get enough native content that is culturally contextual and curated to their choices. “Dashtoon’s mission is to create a world where the art of comic creation is as widespread and culturally ingrained as it is in places like Japan and Korea,” says Lalith Gudipati, COO and Co-founder. “We are thrilled to pioneer a movement that integrates technology and creativity, bringing forth a global creative renaissance in digital comics.” The goal is to build an ecosystem that not only boosts the artistic capabilities and productivity of creators but enables them to monetize their content on Day 1. The readers can access these titles with ease and a user-friendly interface on Dashtoon Comic Reader. With GenAI, the comic book industry has become a greenfield market. Smartphones will become even smarter and more powerful, and the creation will come to mobile devices. This will lead to constant innovations and new formats with a bustling creator-consumer economy, and Dashtoon aims to be at the forefront of it. This funding round will enable Dashtoon to deepen its AI research, progress product development, and content production in the coming months. Naman Lahoty, Principal at Stellaris Venture Partners added: "Content consumption on mobile phones has grown exponentially in the US, from an average of 45 minutes per day in 2011 to a staggering 4 hours per day in 2021. This surge has been fueled by the emergence of new and diverse content formats like short-form videos, audio OTT, podcasts, and casual games that have captivated consumers. Looking ahead, we anticipate that webcomics will emerge as the next wave of growth. As pioneers in this domain, Dashtoon is poised to lead the charge with the founders possesing a perfect mix of content, tech and global user acquisition experience and skills required to build this business.” Aakash Kumar, Managing Director at Matrix Partners India said: “Over several decades content distribution has gone through a phase shift driven by technology, yet we have seen little on the front of content creation being disrupted. In the coming years, the business of content will undergo many transformations and the most important of those is going to be creation getting democratized and boundaries between PGC and UGC getting blurred, and content choices for consumers growing multifold and becoming extensively personalized. We are excited to be partnering with Dashtoon team on their journey to shape this future vision of content.” About Dashtoon Dashtoon is a revolutionary platform that leverages Generative AI technology to enable storytellers worldwide to create illustrated content with unprecedented ease and speed. Dashtoon is curating the best stories globally and visualizing them into comics and graphic novels. Users can discover dazzling universes soaring beyond superheroes and clichés! A realm awaits. It’s as if Manga and HBO teamed up to craft spellbinding comics. For more information, please visit https://dashtoon.com/ About Matrix Partners India Founded in 2006, Matrix Partners India invests in companies targeting the consumer and enterprise market at the seed, early and early growth stages. The firm has invested in several enterprise technology companies such as MoEngage (Customer engagement platform), Toddle (Teaching & learning platform), SuperOps.ai (AI-powered PSA-RMM platform), Rocketlane (Customer onboarding platform), Murf AI (Synthetic speech technology), 100ms (Live video infrastructure) and Atomicwork (Employee success solution) amongst others. Other marquee investments include Dailyhunt (Local language platform), Five Star Business Finance (SME lending), OfBusiness (B2B commerce, fintech), Ola (Mobility), Ola Electric (Electric vehicles), OneCard (Mobile-first credit card), Oxyzo (Tech-enabled smart financing), Razorpay (Payments), Country Delight (D2C dairy & fresh foods brand), GoKwik (E-commerce enablement platform), Jupiter (Neobank), and Mosaic Wellness (Health & wellness), among others. Matrix Partners India has advisory offices in Bangalore, Delhi and Mumbai. Further information is available at www.matrixpartners.in. To know more about our investment philosophy & ideologies, check out the #MatrixMoments podcast series. About Stellaris Venture Partners Stellaris is an early-stage tech-focused VC firm that partners with fearless founders who dream big, think differently, and have an unstoppable desire to challenge the status quo. The fund works with these teams at nascent stages to help transform their ideas into resilient businesses. Stellaris does so with a team of seasoned, diverse operators and entrepreneurs who bring significant experience in building businesses and by providing access to some of the most successful founders and professionals. Since its inception in 2017, Stellaris has backed many market leaders such as Mamaearth, Whatfix, Propelld, Turno, Rigi, and others. For more information on Stellaris Venture Partners, visit https://www.stellarisvp.com. Contact Details Dashtoon Bilal Mahmood +44 7714 007257 b.mahmood@stockwoodstrategy.com Company Website https://dashtoon.com/

November 02, 2023 09:00 AM Eastern Daylight Time

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News Release

TRON (TRX) Partners With ChainGPT, Everlodge (ELDG) and Dogecoin (DOGE) Show Bullish Signals

Total Media

While established players like TRON (TRX) and the internet's favorite meme coin, Dogecoin (DOGE), have enjoyed their time in the limelight, a rising star is making waves in the crypto-sphere. Everlodge (ELDG), a presale phenomenon, is emerging as a strong contender, challenging the dominance of these giants. But what gives it the competitive edge? Keep reading to find out. TRON (TRX): ChainGPT Partnership In a groundbreaking development, TRON (TRX) DAO has solidified a strategic partnership with ChainGPT, a leading AI infrastructure provider for Web3. This alliance is important not just for tech advancements. TRON has millions of users. With more than 100,000 engaging with ChainGPT monthly, this partnership brings resourceful tools to the TRON system and broadens its community. With the promise of AI seamlessly integrated into the TRON blockchain, market analysts are optimistic. Therefore, they have made a bullish TRON price prediction. They foresee the Tron price surging to $0.100 by December 2023. However, those looking for more significant growth are shifting focus to new projects with more real-world applications. Dogecoin (DOGE): Bullish Signals Amid Utility Concerns Dogecoin (DOGE) has recently shown signs of a bullish upturn, attracting attention. Creator Billy Markus added to this excitement by taking to Twitter to share his enthusiasm for the X app's subscriber feature, which has become his new favorite platform. He's planning to engage with subscribers by offering exclusive content, making the Dogecoin community happy. However, despite the excitement among Dogecoin fans and positive growth, the crypto world has a worry: its real-world utility. Sure, Dogecoin gained popularity through memes. But, its primary uses of tips and charity have the crypto world wondering about its future stability. The Dogecoin price has yet to reach $1, as its peak is $0.73. As Dogecoin's fate hangs in the balance, with investors closely watching its performance, experts predict the Dogecoin value will reach $0.098 by December 2023. Everlodge (ELDG): Excellent TRON and Dogecoin Alternative While TRON and Dogecoin have garnered attention primarily for their meme status and speculative trading, Everlodge (ELDG) will bring a real-world use case. This project is unique as it aims to reshape the $4.548T hospitality sector. Everlodge is bringing forward a fractional ownership model for real estate assets using blockchain. This enables users to get a piece of property investments like hotels, with NFTs backing them. So, anyone can participate in high-value real estate investments, not just a privileged few. Moreover, it solves an issue with traditional real estate investment: liquidity. Everlodge users can use their NFT-backed assets as collateral for short-to-medium term loans. With this, investors can access their money without having to sell their piece of real estate. Currently, the ELDG native token is worth only $0.023 because it is in Stage 6 of its presale. Its low market cap gives it a competitive edge over TRON and Dogecoin, as it could experience faster growth. This growth can be noticed now as well. It has already surged by 130% from its starting price. Therefore, experts predict a 3,000% rise for ELDG after its debut. For more information about the Everlodge (ELDG) Presale you can visit their website or join their community here. Contact Details Media Team media@everlodge.io

November 02, 2023 09:00 AM Eastern Daylight Time

Consumer Staples ETF ‘XLP’: A Strategic Investment for Access to Essential Goods Market

Select Sector SPDR

XLP isn't just another fund; it's your personal gateway into the S&P 500's consumer staples sector. Holding shares in household names like Procter & Gamble, Pepsi, Costco, and Coca-Cola – XLP is comprised of the very companies that keep the world's pantries stocked and fridges full. These companies form the backbone of the consumer staples sector, producing goods that are consumed regardless of where we are in the economic cycle. Welcome to Select Sector SPDR’s Consumer Staples ETF ( XLP ) – your opportunity to invest in the everyday essentials that fuel our lives. Gain Exposure to the Everyday Essentials Market Investing in XLP is akin to taking a stroll through the aisles of a grocery store. The fund's holdings span across industries such as food and staples retailing, beverages, food products, tobacco, household goods, and personal care products. This wide array of sectors represents the diverse range of goods that consumers rely on daily. Since its launch in 1998, XLP has amassed over $16 billion in assets under management and maintains a low expense ratio of 0.10%*. It provides a cost-effective solution for investors seeking to access large-cap companies that cater to fundamental consumer needs. A Unique Investment Opportunity Beyond Market Volatility While XLP has proven its resilience during uncertain economic times, it also presents a compelling investment case during periods of economic stability. Consumer staples are everyday items that households continually purchase, making the companies that produce these goods potentially more immune to economic fluctuations. XLP’s top holdings** are Procter & Gamble (14.58%), Costco (10.62%), Pepsi (9.89%), Walmart (9.68%), and Mondelez International (4.62%). By investing in XLP, investors gain exposure to a sector characterized by steady demand. This ETF offers a unique way to invest in the ongoing consumption of essential goods, making it a potential addition to any diversified investment portfolio. DISCLAIMER: This is a work of research and should not be taken as investment or financial advice. Therefore, Select Sector SPDRs or the publisher is not liable for any decision made based on the publication. About the Company: Select Sector SPDR ETFs offer flexibility and customization opportunities. Many investors have similar outlooks, but no two are exactly alike. Select Sector SPDR ETFs let investors select the sectors that best meet their investment goals. *Ordinary brokerage fees apply **Holdings, Weightings & Assets as of 9/30/23 subject to change DISCLOSURES The S&P 500 Index is an unmanaged index of 500 common stocks that is generally considered representative of the U.S. stock market. The index is heavily weighted toward stocks with large market capitalizations and represents approximately two-thirds of the total market value of all domestic common stocks. The S&P 500 Index figures do not reflect any fees, expenses or taxes. An investor should consider investment objectives, risks, fees and expenses before investing. One may not invest directly in an index. Transparent ETFs provide daily disclosure of portfolio holdings and weightings All ETFs are subject to risk, including loss of principal. Sector ETF products are also subject to sector risk and nondiversification risk, which generally will result in greater price fluctuations than the overall market. Diversification does not eliminate risk. An investor should consider investment objectives, risks, charges and expenses carefully before investing. To obtain a prospectus, which contains this and other information, call 1-866-SECTOR-ETF (732-8673) or visit www.sectorspdrs.com. Read the prospectus carefully before investing. ALPS Portfolio Solutions Distributor, Inc., a registered broker-dealer, is distributor for the Select Sector SPDR Trust. Media Contact: Company: Select Sector SPDRs Contact: Dan Dolan* Address: 1290 Broadway, Suite 1000, Denver, CO 80203 Country: United States Email: dan.dolan@sectorspdrs.com Website: https://www.sectorspdrs.com/ *Dan Dolan is a Registered Representative of ALPS Portfolio Solutions Distributor, Inc. ALPS Portfolio Solutions Distributor, Inc., a registered broker-dealer, is the distributor for the Select Sector SPDR Trust. SEL006990 EXP 1/31/24 Contact Details Dan Dolan +1 203-935-8103 dan.dolan@sectorspdrs.com Company Website https://www.sectorspdrs.com/

November 02, 2023 09:00 AM Eastern Daylight Time

Sienna Resources, One Of The Largest Landholders In Nevada’s Lithium-Rich Clayton Valley, Begins Drilling At Elko Lithium Project

Benzinga

By Faith Ashmore, Benzinga In order to achieve energy independence, it is crucial for the United States to focus on the growth of its battery industry, considering the increasing utilization of renewable energy in various sectors. Nevada has rich lithium deposits, making it an ideal location to strengthen the domestic battery sector. Lithium – a vital ingredient in the production of batteries for electric vehicles (EVs), renewable energy storage and electronic devices – plays a crucial role in making this happen. By prioritizing the development of this sector, the United States can lessen its dependence on foreign sources for lithium and battery manufacturing. Sienna Resources Inc. (OTCMKTS: SNNAF) is a company focused on exploring and developing mineral resources, with a specific focus on lithium and graphite. In the energy space, Sienna Resources is actively involved in identifying and acquiring lithium and graphite projects, particularly in regions known for their rich deposits of these minerals. The company aims to contribute to the growing demand for battery materials, as lithium is a key component for electric vehicle batteries and renewable energy storage. The company is making progress in the energy space, particularly in the lithium sector. Sienna has recently acquired the Elko Lithium Project in Elko County, Nevada, and will begin drilling soon. This project covers approximately 1,200 acres and is in close proximity to Surge Battery Metals' (OTCQX: NILIF) Nevada North Lithium Project, which has yielded high-grade lithium values according to recent reports. Sienna Resources has also recently completed the acquisition of the Silver Peak South Lithium Project (SPSLP), located in Clayton Valley, Nevada. This project connects with Sienna's existing Blue Clay Lithium Project, creating a continuous block of approximately 4,700 acres. With these acquisitions, Sienna has become one of the largest landholders in Clayton Valley. The company is strategically positioned in Clayton Valley, where many developments are taking place. Sienna is working on the pilot plant for lithium clay extraction by Century/Koch Technology Solutions. The results of this pilot plant could have a substantial impact on the industry. Another crucial development is the final analysis of the Schlumberger (NYSE: SLB) DLE pilot plant for brine on Pure Energy's property. This brine basin is home to the only producing lithium project in North America, Albemarle Corporation's (NYSE: ALB) Silver Peak deposit. Sienna Resources, along with Albemarle and Schlumberger, is involved in exploring this region, with each company playing a unique role. Sienna Resources reports it has sufficient funds to support its planned work, with over $2 million in the bank. This seems like an opportune time for the company to commence multiple lithium projects in Nevada, and they are also planning an aggressive marketing program to coincide with their upcoming work programs. The lithium deposits in Nevada, particularly in Clayton Valley, seem to hold promise and may be critical to helping the U.S. achieve energy independence. The region is already home to Albemarle's Silver Peak deposit, the only lithium-producing project in North America. With the increasing global demand for lithium, the development of lithium projects in this region is crucial for meeting the growing needs of the electric vehicle and renewable energy industries. Sienna Resources' presence in Nevada positions them to contribute to the domestic battery industry, reducing reliance on foreign sources of lithium and supporting the country's transition to cleaner and more sustainable energy sources. This post contains sponsored content. This content is for informational purposes only and not intended to be investing advice. Contact Details Benzinga +1 877-440-9464 info@benzinga.com Company Website http://www.benzinga.com

November 02, 2023 09:00 AM Eastern Daylight Time

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